NX-1607 (Nx1607) | Cbl-b inhibitor | Probechem Biochemicals

Chemical Structure : NX-1607

CAS No.: 2573775-59-2

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NX-1607 (Nx1607, Nx-1607)

货号: PC-21554Not For Human Use, Lab Use Only.

Nx-1607 (Nx1607) is a small-molecule inhibitor of the RING-type E3 ubiquitin ligase Cbl-b with IC50 of 0.46 nM.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
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生物&药学活性

Nx-1607 (Nx1607) is a small-molecule inhibitor of the RING-type E3 ubiquitin ligase Cbl-b with IC50 of 0.46 nM.
Nx-1607 binds to the TKBD-LHR unit of Cbl-b, locking the protein in an inactive conformation.
Nx-1607 inhibits the interaction between the N-terminal E3 ligase fragment (TKBD-LHR-RING) of Cbl-b and UbcH5B-Ub (E2-Ub) complex in the presence of the Src kinase substrate.

物理化学性质&存储条件

分子量	537.63
分子式	C30H34F3N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-((1s,3R)-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl)phenyl)-6-(((S)-3-methylpiperidin-1-yl)methyl)-4-(trifluoromethyl)isoindolin-1-one

参考文献

1. Serah W Kimani, et al. Commun Biol. 2023 Dec 16;6(1):1272.

NX-1607 (Nx1607, Nx-1607)

生物&药学活性

物理化学性质&存储条件

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NX-1607 (Nx1607, Nx-1607)

生物&药学活性

物理化学性质&存储条件

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