欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-ATM/ATR-WSD0628
WSD0628

Chemical Structure : WSD0628

CAS No.: 2765448-96-0

加入收藏

WSD0628 (WSD-0628)

货号: PC-24377Not For Human Use, Lab Use Only.

WSD0628 (WSD-0628) is a potent, selective, orally bioavailable and CNS penetrant ATM inhibitor, potently inhibits ATM-mediated phosphorylation of the DNA damage response protein KAP1 in MCF-7 cells with IC50 of 0.42 nM.

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    WSD0628 (WSD-0628) is a potent, selective, orally bioavailable and CNS penetrant ATM inhibitor, potently inhibits ATM-mediated phosphorylation of the DNA damage response protein KAP1 in MCF-7 cells with IC50 of 0.42 nM.
    WSD0628 is much less potent inhibition of the related kinases ATR (phosphorylation of CHK1, IC50 742nM) or DNA-PKcs (auto-phosphorylation of DNA-PK, IC50 169nM) in HT29 cells.
    WSD-0628 (30 nM) potently inhibited RT-induced phospho-KAP1 and robustly reduced clonogenic survival by 5-fold when combined with 5 Gy irradiation in U251 GBM cells.
    WSD0628 is orally bioavailable and CNS penetrant without efflux transporter liability.

    物理化学性质&存储条件

    分子量 439.47
    分子式 C23H23F2N5O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-1-(3,3-Difluoro-1-methylpiperidin-4-yl)-8-(6-methoxypyridin-3-yl)-3-methyl-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one

    参考文献

    1. Rathi S, et al. J Pharmacol Exp Ther. 2024 Jul 18;390(2):260-275.

    2. Tuma, A. M. et al. Abstract 3305: WSD-0628, a novel brain penetrant ATM inhibitor, radiosensitizes GBM and melanoma patient derived xenografts. Cancer Res. 2022, 82, 3305– 3305.

    备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    联系我们 sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    询单

    • *产品名称:
    • *姓名:
    • *邮箱:
    • *公司名称:
    • *询单数量:
    • *国籍:
    • 询单信息: