Isoxazole 1 | CnAcs1 inhibitor | Probechem Biochemicals

Chemical Structure : Isoxazole 1

加入收藏

Isoxazole 1 (CnAcs1 inhibitor)

货号: PC-25620Not For Human Use, Lab Use Only.

Isoxazole 1 is a potent, specific inhibitor of C. neoformans acetyl-CoA synthetase (CnAcs1) with IC50 of 8.6 uM, shows antifungal activity against WT C. neoformans strain H99 with MIC of 2 ug/mL.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Isoxazole 1 is a potent, specific inhibitor of C. neoformans acetyl-CoA synthetase (CnAcs1) with IC50 of 8.6 uM, shows antifungal activity against WT C. neoformans strain H99 with MIC of 2 ug/mL.
Isoxazole 1 inhibits the growth of H99 with a MIC of 32 ug/mL.
shows no antifungal activity against C. albicans or C. glabrata, two Candida spp. which lack Acl enzymes.
Isoxazole 1 is synergistic with fluconazole in vitro, with a Fractional Inhibitory Concentration Index (FICI) of 0.5.
Isoxazole 1 is also synergistic with rapamycin against C. neoformans (FICI = 0.5).
Isoxazole 1 does not inhibit Saccharomyces cerevisiae Acs1 (ScAcs1), Candida albicans Acs2 (CaAcs2), Aspergillus fumigatus Acs1 (AfAcs1), Coccidioides immitis Acs1 (CiAcs1), and Cryptococcus neoformans Acs1 (CnAcs1), and human acetyl-CoA synthetase ACSS2.

物理化学性质&存储条件

分子量	374.44
分子式	C23H22N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((5-cyclopropylisoxazol-3-yl)methyl)-3-(2,3-dihydrobenzofuran-5-yl)-N-methylbenzamide

参考文献

1. Jezewski AJ, et al. Nat Commun. 2025 Oct 14;16(1):9118.