PanK inhibitor MNS

Chemical Structure : PanK inhibitor MNS

CAS No.: 22568-48-5

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货号: PC-24659Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PanK inhibitor MNS is a broad-spectrum antifungal, fungal-selective inhibitor of PanK with IC50 of 1.13 μM and 17.74 μM against CaCab1p and AfPanKp respectively, directly engages and inhibits PanK to block CoA production.
MNS exerts relatively potent antifungal activity against the C. albicans reference strain – SC5314 (CAB1/CAB1), with an MIC50 of 1.95-3.9 μM.
MNS does not inhibit human PanK1 at any concentration tested (IC50 > 400 μM).
MNS shows dose-dependent reductions in intracellular CoA concentrations in treated wild-type C. albicans cells.
MNS (0.1 mg/kg/day) has antifungal efficacy in a mouse model of disseminated Candida albicans infection.

物理化学性质&存储条件

分子量	193.16
分子式	C9H7NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-5-(2-nitrovinyl)benzo[d][1,3]dioxole

参考文献

1. Regan J, et al. Cell Chem Biol. 2025 May 15;32(5):710-721.e6.