Inz-5 | Fungal complex III inhibitor | Probechem Biochemicals

Chemical Structure : Inz-5

CAS No.: 1585214-21-6

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Inz-5 (Fungal CIII inhibitor)

货号: PC-27585Not For Human Use, Lab Use Only.

Inz-5 is a fungal-specific indazole derivative inhibitor of Candida albicans (C. albicans) complex III (CIII) with IC50 of 24 nM in UQH2:cyt c oxidoreductase assays.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Inz-5 is a fungal-specific indazole derivative inhibitor of Candida albicans (C. albicans) complex III (CIII) with IC50 of 24 nM in UQH2:cyt c oxidoreductase assays.
Inz-5 binds within the QP site of homodimeric respiratory complex III (CIII2).
Inz-5 is specific for fungal CIII.
Inz-5 is a Pm-type inhibitor, binds similar to strobilurin-type inhibitors.
Inz-5 enhances antifungal action of both voriconazole and caspofungin.

物理化学性质&存储条件

分子量	390.35
分子式	C18H14F4N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-fluoro-5-(trifluoromethyl)phenyl)-7-methyl-1-((2-methyl-2H-tetrazol-5-yl)methyl)-1H-indazole

参考文献

1. Di Trani JM, et al. Structure. 2022 Jan 6;30(1):129-138.e4.

2. Phan-Canh T, et al. ACS Infect Dis. 2026 Jul 28. doi: 10.1021/acsinfecdis.5c01058.

Inz-5 (Fungal CIII inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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Inz-5 (Fungal CIII inhibitor)

生物&药学活性

物理化学性质&存储条件

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