欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-GPCR-5-HT Receptor-IHCH-8110
IHCH-8110

Chemical Structure : IHCH-8110

CAS No.: 3078735-55-1

加入收藏

IHCH-8110 (IHCH8110)

货号: PC-27530Not For Human Use, Lab Use Only.

IHCH-8110 is a potent, selective, non-brain-penetrant, peripheral-restricted serotonin 2A receptor (5-HT2AR) agonist with Ki of 47.86 nM, inhibits CRC progression by activating 5-HT2AR on enteric glial cells.

规格 价格 库存 数量
2 mg ￥2180 In stock
5 mg ￥3580 In stock
10 mg ￥5580 In stock
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

IHCH-8110 is a potent, selective, non-brain-penetrant, peripheral-restricted serotonin 2A receptor (5-HT2AR) agonist with Ki of 47.86 nM, inhibits CRC progression by activating 5-HT2AR on enteric glial cells.
IHCH-8110 acts as an agonist at both 5-HT2AR and 5-HT2CR in functional assays, including calcium flux and β-arrestin2 recruitment, also functions as a 5-HT2BR antagonist.
IHCH-8110 exhibits no detectable functional activity at other GPCR family 5-HT receptors or dopamine receptors.
IHCH-8110 suppresses CRC progression by enhancing CD8+ T cell antitumor functions.
IHCH-8110 targets enteric glial cells (EGCs) expressed on EGCs to inhibit tumor growth.
IHCH-8110 enhances the recruitment and polarization of CD8+ T cells by upregulating EGC-derived CXCL10 and IL-18.
IHCH-8110 sensitizes immune-cold CRC to anti-PD-1 therapy.

物理化学性质&存储条件

分子量 361.53
分子式 C21H35N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Urea, N-(trans-4-aminocyclohexyl)-N′-[[4-(hexyloxy)phenyl]methyl]-N-methyl-

参考文献

1. Wen Y, et al. Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer. Cell. 2026 Aug 4:S0092-8674(26)00826-3.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: