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首页-小分子抑制剂&激动剂-TGF-beta/Smad-TGF beta Receptor (TGFBR)-NUCC-555
NUCC-555

Chemical Structure : NUCC-555

CAS No.: 1060469-90-0

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NUCC-555 (NUCC555)

货号: PC-21392Not For Human Use, Lab Use Only.

NUCC-555 is a selective antagonist of Activin antagonist, shows dose-dependent antagonistic activity against activin A-stimulated FSHβ promoter activation in 338FSHβ-luc LβT2 cells with IC50 of 3.67 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NUCC-555 is a selective antagonist of Activin antagonist, shows dose-dependent antagonistic activity against activin A-stimulated FSHβ promoter activation in 338FSHβ-luc LβT2 cells with IC50 of 3.67 uM.
    NUCC-555 binds to the activin A:ActRII that disrupts the activin A:ActRII complex's binding with ALK4-ECD-Fc in a dose-dependent manner.
    NUCC-555 also specifically binds to activin A compared with other TGFβ superfamily member myostatin (GDF8).
    NUCC-555 completely blocks activin A/ActRIIA complex binding with ALK4 at 25 uM, shows no blocking activity to the myostatin/ActRIIA complex binding with ALK4.
    NUCC-555 not only strongly antagonizes function against activin A but also has selectivity for binding to activin A over other TGFβ superfamily members, such as myostatin.
    NUCC-555 (30 or 60 mg/kg) treatment induces a dose-dependent decrease in FSH levels in ovariectomized mice.

    物理化学性质&存储条件

    分子量 443.51
    分子式 C25H25N5O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-benzyl-1-ethyl-5-(2-methoxyacetamido)-2-(pyridin-3-yl)-1H-benzo[d]imidazole-7-carboxamide

    参考文献

    1. Jie Zhu, et al. J Med Chem. 2015 Jul 23;58(14):5637-48.

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