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首页-小分子抑制剂&激动剂-TGF-beta/Smad-TGF beta Receptor (TGFBR)-RK783
RK783

Chemical Structure : RK783

CAS No.: 2231720-21-9

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RK783 (RK-783)

货号: PC-24853Not For Human Use, Lab Use Only.

RK783 is a potent, selective inhibitor inhibitor of BMP type 1 receptor kinase (ACVR1), inhibits CVR1-Q207D, ACVR1-R206H, wild-type ACVR1, and other BMP type 1 receptor kinases with IC50 of 10-120 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

RK783 is a potent, selective inhibitor inhibitor of BMP type 1 receptor kinase (ACVR1), inhibits CVR1-Q207D, ACVR1-R206H, wild-type ACVR1, and other BMP type 1 receptor kinases with IC50 of 10-120 nM.
RK783 preferentially suppressed both basal and stimulated BMP-Smad1/5/9 signaling in vitro without affecting the signaling of Smad2/3.
RK783 specifically suppress BMP-Smad signaling and prevent HO formation in both the ACVR1-R206H and ACVR1-Q207D mouse efficacy models.
RK783 can also induce myofiber repair and inflammation infiltration.

物理化学性质&存储条件

分子量 482.59
分子式 C27H30N8O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(1-ethyl-3-(pyridin-3-yl)-1H-pyrazol-4-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)pyrimidin-2-amine

参考文献

1. Jingwen Yang, et al. Bone. 2025 Jun 18:199:117565.

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