| Cat. No. |
Product Name |
Information |
| PC-42160 |
HO-3867
STAT3 inhibitor
|
HO-3867 is a synthetic curcuminoid that selectively inhibits STAT3 phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs. |
| PC-42175 |
SH5-07
STAT3 inhibitor
|
SH5-07 (SH-5-07, SH 5-07) is a potent, selective small-molecule STAT3 inhibitor with IC50 of 3.9 uM. |
| PC-45109 |
SH-4-54
STAT3 inhibitor
|
SH-4-54 is a potent, BBB permeable, nonphosphorylated STAT3 inhibitor that strongly binds to STAT3 protein with Kd of 300 nM. |
| PC-43790 |
Napabucasin
STAT3 inhibitor
|
Napabucasin (BBI608) is a potent small-molecule inhibitor of STAT3 that has a broad spectrum of activity against stemness-high cancer cells (IC50=0.5-1.5 uM). |
| PC-42210 |
AS1517499
STAT6 inhibitor
|
AS1517499 is a novel potent STAT6 inhibitor with IC50 of 21 nM in STAT6-dependent promoter reporter assay. |
| PC-25579 |
Bt354
STAT3 inhibitor
|
Bt354 is a specific, small-molecule inhibitor of the STAT3 signalling pathway, prevents STAT3 from entering the nucleus and phosphorylates it at Y705, exhibiting potent anticancer properties. |
| PC-25480 |
Stafori-2
STAT4 inhibitor
|
Stafori-2 is the phosphate analog of Stafori-1 and potent, selective small molecule inhibitor of STAT4 Src homology 2 domain with Ki of 0.18 uM in FP assays, shows good selectivity over other STAT family members. |
| PC-25392 |
Colivelin TFA
STAT3 agonist
|
Colivelin TFA is a femtomolar-acting humanin derivative, hybrid neuroprotective peptide and potent activator of STAT3, suppresses neuronal death induced by insults related to Alzheimer's disease (AD) by activating STAT3 in vitro. |
| PC-25391 |
Colivelin
STAT3 agonist
|
Colivelin is a femtomolar-acting humanin derivative, hybrid neuroprotective peptide and potent activator of STAT3, suppresses neuronal death induced by insults related to Alzheimer's disease (AD) by activating STAT3 in vitro. |
| PC-25382 |
Brevilin A
STAT3 inhibitor, LRRC15 inhibitor
|
Brevilin A is an orally active STAT3/JAK inhibitor with IC50 of 10.6 uM (STAT3), exerts potent anti-inflammatory, antitumor, immunosuppressive, and anti-liver fibrosis effects, also reduces protein levels of LRRC15 in RA fibroblast-like synoviocytes (RA-FLSs). |
| PC-25257 |
WR-S-462
STAT3 inhibitor
|
WR-S-462 is a highly potent and selective STAT3 inhibitor with SPR Kd of 58 nM, directly interferes with the STAT3-SH2 domain interaction. |
| PC-25251 |
LZJ66
STAT3 inhibitor
|
LZJ66 (STAT3-IN-20, Compound 40) is a potent, selective STAT3 inhibitor, inhibits L-6/JAK/STAT3 signaling pathway with IC50 of 0.65 uM. |
