| Cat. No. |
Product Name |
Information |
| PC-73110 |
SI-109
STAT3 inhibitor
|
SI-109 (SI 109) is a selective, high-affinity and cell-permeable STAT3 SH2 domain inhibitor with Ki of 9 nM, component of STAT3 degrader SD-36 (PROTAC). |
| PC-72849 |
SS-4
STAT3 inhibitor
|
SS-4 is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo. |
| PC-72002 |
Stat3 inhibitor H182
STAT3 inhibitor
|
Stat3 inhibitor H182 is a potent, selective STAT3 inhibitor, inhibits Stat3 DNA-binding activity with IC50 of 0.66 uM. |
| PC-38322 |
Stafia-1 prodrug
STAT5a inhibitor
|
Stafia-1 prodrug is the cell-permeable prodrug of Stafia-1 (Cat. PC-38321), and is suitable for cell based assays, inhibits tyrosine phosphorylation of STAT5a with selectivity over STAT5b in cultured human leukemia cells. |
| PC-38321 |
Stafia-1
STAT5a inhibitor
|
Stafia-1 is a selective inhibitor of STAT5a with Ki of 10.9 uM, preferentially inhibits STAT5a over the close homologue STAT5b (>9-fold) and other STAT family member. |
| PC-35089 |
PM-43I
STAT5/6 inhibitor
|
PM-43I is a selective inhibitor of STAT5/6 Src Homology 2 (SH2) domain, binds recombinant STAT6 and STAT5B (IC50=1.8 and 3.8 uM) with much lower affinity for STAT3 (IC50=29.9 uM). |
| PC-63206 |
KI16
STAT3 inhibitor
|
KI16 is a novel small molecules that inhibit STAT3-dependent transcription and function, interacts with the STAT3 SH2 domain. |
| PC-63164 |
TRi-1
TXNRD1 inhibitor
|
TRi-1 (TXNRD1 inhibitor 1) is a potent, specific and irreversible inhibitor of cytosolic thioredoxin reductase 1 (TXNRD1) with anticancer potential, 5- to 10-fold higher specificity for TXNRD1 over TXNRD2. |
| PC-63081 |
PG-S3-001
STAT3 inhibitor
|
PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance. |
| PC-62863 |
NSC 368262
STAT3 inhibitor
|
NSC 368262 is a selective STAT3 inhibitor that alkylates Cys468 in Stat3, blocks the DNA-binding activity of phosphorylated Stat3 homodimers with IC50 of 10-50 uM, without inhibiting the DNA-binding of phosphorylated Stat1 homodimers. |
| PC-62576 |
QD 232
STAT3 inhibitor
|
QD 232 is a novel quinazolinedione-based redox modulator that potently inhibits Src/FAK and STAT3 phosphorylation, decreasing pancreatic cancer cell viability and migration. |
| PC-62556 |
AC-4-130
STAT5 inhibitor
|
AC-4-130 is a novel, potent STAT5 SH2 domain inhibitor, binds to and efficiently blocks STAT5 activation and subsequent transcriptional activity, shows high selectivity for STAT5 over STAT1 and STAT3. |
