Narciclasine | STAT3 inhibitor, Rho activator | Probechem Biochemicals

Chemical Structure : Narciclasine

CAS No.: 29477-83-6

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Narciclasine (Lycoricidinol)

货号: PC-28407Not For Human Use, Lab Use Only.

Narciclasine is a potent antimitotic substance isolated from Narcissus bulbs, blocks peptide bond formation by eukaryotic ribosomes, activates Rho and stress fibers in glioblastoma multiforme cells, modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway also degraders STAT3 by directly binding with the STAT3 SH2 domain.

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10 mg	￥5580	In stock
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生物&药学活性

Narciclasine is a potent antimitotic substance isolated from Narcissus bulbs, blocks peptide bond formation by eukaryotic ribosomes, activates Rho and stress fibers in glioblastoma multiforme cells, modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway also degraders STAT3 by directly binding with the STAT3 SH2 domain.

物理化学性质&存储条件

分子量	307.26
分子式	C14H13NO7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3R,4S,4aR)-2,3,4,7-Tetrahydroxy-3,4,4a,5-tetrahydro-[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one

参考文献

1. Ceriotti G. Nature. 1967 Feb 11;213(5076):595-6.

2. Carrasco L, et al. FEBS Lett. 1975 Apr 1;52(2):236-9.

3. Lefranc F, et al. Mol Cancer Ther. 2009 Jul;8(7):1739-50.

4. Lv C, et al. Mol Ther Oncolytics. 2022 Jan 3;24:340-354.

Narciclasine (Lycoricidinol)

生物&药学活性

物理化学性质&存储条件

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Narciclasine (Lycoricidinol)

生物&药学活性

物理化学性质&存储条件

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