Pomstafib-2-CR

Chemical Structure : Pomstafib-2-CR

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货号: PC-26212Not For Human Use, Lab Use Only.

Pomstafib-2-CR is the ester prodrug of Stafib-2-CR, which is highly potent, selective inhibitor of transcription factor STAT5b with IC50 of 26 nM.

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生物&药学活性

Pomstafib-2-CR is the ester prodrug of Stafib-2-CR, which is highly potent, selective inhibitor of transcription factor STAT5b with IC50 of 26 nM.
Pomstafib-2-CR inhibits phosphorylation of STAT5b-GFP with an IC50 of 1.0 µM in K562 cells.
Pomstafib-2-CR inhibits phosphorylation of STAT5b-GFP on Tyr699, but not STAT5a-GFP on Tyr694.

物理化学性质&存储条件

分子量	1127.08
分子式	C54H68N2O20P2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((((2-(2-(4-((4-phenoxyphenyl)carbamoyl)phenoxy)acetyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diyl)bis(oxy))bis(oxo-l5-phosphanetriyl))tetrakis(oxy))tetrakis(methylene) tetrakis(2,2-dimethylpropanoate)

参考文献

1. Münzel T, et al. Chemistry. 2025 Nov 30:e02809.

Pomstafib-2-CR

生物&药学活性

物理化学性质&存储条件

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Pomstafib-2-CR

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物理化学性质&存储条件

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