W1307 | STAT3 inhibitor | Probechem Biochemicals

Chemical Structure : W1307

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W1307 (W-1307)

货号: PC-27106Not For Human Use, Lab Use Only.

W1307 is a potent and highly selective STAT3 inhibitor with SPR KD of 1.74 uM, demonstrates significant anti-tumor activity both in vitro and in vivo.

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生物&药学活性

W1307 is a potent and highly selective STAT3 inhibitor with SPR KD of 1.74 uM, demonstrates significant anti-tumor activity both in vitro and in vivo.
W1307 binds to and stabilizes the STAT3 protein in AML cells in CETSA assays.
W1307 (0-3 uM) inhibits Tyr705 phosphorylation of STAT3 in a time-dependent manner in K562 and MOLM-13, suppresses the expression of its downstream targets (c-Myc, Mcl-1, and Bcl-2), without affecting STAT1/5 phosphorylation, nor phospho-AKT levels, the upstream kinase of STAT3.
W1307 disrupts STAT3-STAT3 dimerization in 293T cells for Co-IP analysis.
W1307 strongly suppresses AML cell proliferation, survival and induces apoptosis.
W1307 (5 or 15 mg/kg) exhibited significant, dose-dependent anti-leukemic effects in murine AML model by intravenously injecting MOLM-13-EGFP/Luc cells into NOD-SCID mice.
W1307 enhances the anti-tumor effect of Ara-C and sensitizes resistant AML cell line to Ara-C through disrupting lipid homeostasis and triggering lipotoxicity.

物理化学性质&存储条件

分子量	345.36
分子式	C20H15N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-methoxy-N-(oxazol-2-yl)-2-phenylquinoline-4-carboxamide

参考文献

1. Peng K, et al. Cell Death Dis. 2026 Jun 17. doi: 10.1038/s41419-026-08988-4.

W1307 (W-1307)

生物&药学活性

物理化学性质&存储条件

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W1307 (W-1307)

生物&药学活性

物理化学性质&存储条件

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