HUHS199 | ALKBH3 inhibitor | Probechem Biochemicals

Chemical Structure : HUHS199

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HUHS199 (HUHS-199)

货号: PC-28039Not For Human Use, Lab Use Only.

HUHS199 is a potent small molecule inhibitor of prostate cancer antigen-1 (PCA-1, ALKBH3), potently inhibits the RNA demethylase activity of ALKBH3 with IC50 of 0.17 uM in ELISA assays.

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

HUHS199 is a potent small molecule inhibitor of prostate cancer antigen-1 (PCA-1, ALKBH3), potently inhibits the RNA demethylase activity of ALKBH3 with IC50 of 0.17 uM in ELISA assays.
HUHS199 significantly inhibits cell proliferation in a concentration-dependent manner on U251MG GBM cells, via G1 arrest of cell cycle.
HUHS199 increases m1A levels of RNA in U251MG cells.
HUHS199 inhibits the RNA demethylase activity of ALKBH3, thereby increasing the m1A levels of GADD45A, one of its substrates, increase enhances GADD45A stability and, through interaction with p21, induces G1 phase cell cycle arrest in GBM cells.

物理化学性质&存储条件

分子量	415.51
分子式	C20H25N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-cyclohexyl-2-(3-hydroxy-4,5,6,7-tetrahydro-2H-indazol-2-yl)-1H-benzo[d]imidazole-5-sulfonamide

参考文献

1. Yamada M, et al. Chem Biol Drug Des. 2026 Sep;108(3):e70385.

2. Patent JP2019052096 A 2019-04-04.

HUHS199 (HUHS-199)

生物&药学活性

物理化学性质&存储条件

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HUHS199 (HUHS-199)

生物&药学活性

物理化学性质&存储条件

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