| Cat. No. |
Product Name |
Information |
| PC-24839 |
NGI-186
Oligosaccharyltransferase inhibitor
|
NGI-186 is a potent, small molecule inhibitor of oligosaccharyltransferase (OST) with IC50 of 0.06 uM. |
| PC-24838 |
NGI-190
Oligosaccharyltransferase inhibitor
|
NGI-190 is a potent, small molecule inhibitor of oligosaccharyltransferase (OST) with IC50 of 0.59 uM. |
| PC-24837 |
NGI-189
Oligosaccharyltransferase inhibitor
|
NGI-189 is a potent, small molecule inhibitor of oligosaccharyltransferase (OST) with IC50 of 0.09 uM. |
| PC-24792 |
VG-3927
TREM2 agonist
|
VG-3927 (I-192) is a highly potent, selective and brain penetrant triggering receptor expressed on myeloid cells 2 (TREM2) agonist. |
| PC-24788 |
SANA
Thermogenesis inducer
|
SANA is a nitroalkene derivative of salicylate, and a first-in-class activator of creatine-dependent energy expenditure and thermogenesis, induces creatine-dependent thermogenesis and promotes weight loss. |
| PC-24750 |
SNT-5382
LOXL2 inhibitor
|
SNT-5382 is a potent, selective and irreversible LOXL2 inhibitor with IC50 of 10 nM, exhibits rapid, time-dependent LOXL2 inhibition and competitively binds to the active site of LOXL2. |
| PC-24661 |
Core Circadian Modulator
BMAL1 ligand
|
Core Circadian Modulator (CCM) is specific small molecule BMAL1 ligand, targets the cavity in the PASB domain of BMAL1 with ITC Kd of 1.99 uM, modulates BMAL1-CLOCK target gene expressions. |
| PC-24650 |
Cucurbitacin B
IGF2BP1 inhibitor
|
Cucurbitacin B (CuB) is a potent but toxic anticancer natural product, an irreversible covalent inhibitor of IGF2BP1 and forms a covalent bond with cysteine 253 of the IGF2BP1 KH 1-2 domain (KD=66.8 nM). |
| PC-24626 |
RJG-2036
PTGR2 inhibitor
|
RJG-2036 is a potent, selective, covalent prostaglandin reductase 2 (PTGR2) inhibitor with IC50 of 100 nM (human PTGR2), covalently ligands the noncatalytic Y100 and Y265 residues located in the substrate binding pocket. |
| PC-24621 |
Fis1 inhibitor SP11
Fis1 inhibitor
|
SP11 is a potent inhibitor of activated Fis1 (mitochondrial fission protein 1), covalently binds specifically to Cys41 of activated Fis1, inhibits CPM fluorescence of Thr34Asp Fis1 with IC50 of 9.4 uM. |
| PC-24616 |
ORIC-533
CD73 inhibitor
|
ORIC-533 is a potent, selective, AMP-competitive and orally bioavailable ectonucleotidase CD73 inhibitor. |
| PC-24596 |
SALL4 inhibitor SH6
SALL4 degrader
|
SALL4 inhibitor SH6 is a small molecule inhibitor of transcription factor SALL4 ZFC4 domain, selectively targets SALL4-expressing cancer cells (EC50=0.5 uM, SNU398 cells), degrades SALL4 protein through the CUL4A/CRBN pathway. |
