Core Circadian Modulator | BMAL1 ligand | Probechem Biochemicals

Chemical Structure : Core Circadian Modulator

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Core Circadian Modulator (CCM)

货号: PC-24661Not For Human Use, Lab Use Only.

Core Circadian Modulator (CCM) is specific small molecule BMAL1 ligand, targets the cavity in the PASB domain of BMAL1 with ITC Kd of 1.99 uM, modulates BMAL1–CLOCK target gene expressions.

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生物&药学活性

Core Circadian Modulator (CCM) is specific small molecule BMAL1 ligand, targets the cavity in the PASB domain of BMAL1 with ITC Kd of 1.99 uM, modulates BMAL1–CLOCK target gene expressions.
CCM induces dose-dependent alterations in PER2–Luc oscillations and orchestrates the downregulation of inflammatory and phagocytic pathways in macrophages.
Unlike BMAL1 knockdown, CCM treatment preserves BMAL1 protein levels while modulating its transcriptional activity as a pioneer factor.
CCM treatment resulted in decreased expression levels of core TTFL components CRY1, CRY2, PER2 and PER3 while modestly increasing levels of NR1D1, RORA and RORB in U2OS cells
CCM as a highly specific pharmacological tool for understanding the consequences of targeting this pocket in BMAL1–CLOCK functions.

物理化学性质&存储条件

分子量	238.26
分子式	C13H15FO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((4-ethylbenzofuran-7-yl)oxy)-2-fluoropropan-1-ol

参考文献

1. Pu H, et al. Nat Chem Biol. 2025 May;21(5):736-745.

Core Circadian Modulator (CCM)

生物&药学活性

物理化学性质&存储条件

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Core Circadian Modulator (CCM)

生物&药学活性

物理化学性质&存储条件

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