| Cat. No. |
Product Name |
Information |
| PC-26781 |
C26-Ceramide
121459-09-4
|
C26 Ceramide is a lipid featuring two hydrophobic tails, one saturated and the other unsaturated, can be used in developing lipid nanoparticles or liposomes. |
| PC-26779 |
(Z)-Ligustilide
CAS 81944-09-4
|
(Z)-Ligustilide is an orally active natural compound from Ligusticum chuanxiong Hort, has antimicrobial and antifungal activity, inhibits the expression of FATP5 and DGAT, inhibits fatty acid uptake and esterification in mice and has potential as therapeutics for nonalcoholic fatty liver disease (NAFLD). |
| PC-26778 |
Ligustilide
MEOX1 inhibitor
|
Ligustilide is a potential inhibitor of mesenchyme homeobox 1 (MEOX1), exhibits neuroprotective, anti-cancer, anti-inflammatory, and vasodilator effects, exerts significant antifibrotic effects through inhibition of MEOX1 and the downstream of the Hippo signalling pathway. |
| PC-26771 |
Kukoamine A
Trypanothione reductase inhibitor
|
Kukoamine A (KuA) is a potent and selective inhibitor of Crithidia fasciculata trypanothione reductase (TR) with Ki of 1.8 uM, with no significant inhibition on human glutathione reductase, possesses antioxidant, anti-inflammatory activities. |
| PC-26770 |
MEDS613
DHODH inhibitor
|
MEDS613 is a potent, selective hDHODH inhibitor with IC50 of 4.1 nM. |
| PC-26766 |
Acetyl-6-formylpterin
MAIT cell inhibitor, MR1 ligand/upregulator
|
Acetyl-6-formylpterin (Ac-6-FP, Acetyl-6-FP) is a small molecule ligand of MHC-related class I-like molecule MR1, markedly stabilizes MR1, potently up-regulates MR1 cell surface expression, and inhibits MAIT cell activation. |
| PC-26765 |
GAA-4OH
DEGS1 inhibitor
|
GAA-4OH is a potent and irreversible inhibitor of dihydroceramide desaturase-1 (DEGS1), covalently blocks the enzyme catalytic cavity, reduces ceramide-to-dihydroceramide ratios and improves steatosis, inflammation, and fibrosis in mouse model of MASLD. |
| PC-26755 |
ELOVL1-IN-2
ELOVL1 inhibitor
|
ELOVL1-IN-2 is a specific ELOVL1 inhibitor with IC50 of 21 μM, inhibits the condensation step of fatty acid elongation and reduces the synthesis of very long-chain fatty acids, including C26:0 VLCFA. |
| PC-26747 |
HNF4α agonist (Z)-19
HNF4α agonist
|
HNF4α agonist (Z)-19 is a small molecule agonist of hepatocyte nuclear factor 4 alpha (HNF4α) with EC50 of 9.2 uM and SPR KD of 4.6 uM. |
| PC-26745 |
TTBK1/2-IN-1
TTBK1/2 inhibitor
|
TTBK1/2-IN-1 (Compound 3) is a potent tau tubulin kinase 1 and 2 (TTBK1 and TTBK2) inhibitor with IC50 of 816 nM and 384 nM nM for TTBK1 and TTBK2, respectively. |
| PC-26744 |
TTBK1-IN-2
TTBK1 inhibitor
|
TTBK1-IN-2 (Compound 29) is a potent, brain penetrant Tau-Tubulin kinase (TTBK1) inhibitor with IC50 of 0.24 uM, reduces TDP-43 phosphorylation both in vitro and in vivo. |
| PC-26743 |
TTBK inhibitor 13
TTBK inhibitor
|
TTBK inhibitor 13 (TTBK1/2 inhibitor) is a potent and cell active tau tubulin kinase 1 and 2 (TTBK1 and TTBK2) inhibitor with IC50 of 3 nM and 2.8 nM for TTBK1 and TTBK2, respectively. |
