| Cat. No. |
Product Name |
Information |
| PC-24743 |
Kifunensine
alpha-mannosidase I inhibitor
|
Kifunensine (FR-900494) is a potent inhibitor of glycoprotein processing mannosidase I (alpha-mannosidase I) with IC50 of 20-50 nM, inactive toward the plant mannosidase II, kifunensine also inhibits the Golgi mannosidase I in rat liver microsomes. |
| PC-24721 |
Cavolin-1 ligand WL47
Caveolin-1 inhibitor
|
Cavolin-1 ligand WL47 is a peptide, high-affinity, selective disrupter / inhibitor of caveolin-1 (CAV) oligomerization with ITC KD of 23 nM, 7500-fold improved affinity compared to its T20 parent ligand. |
| PC-24712 |
ROR1 inhibitor 24d
ROR1 inhibitor
|
ROR1 inhibitor 24d is a potent, selective inhibitor of receptor tyrosine kinase-like orphan receptor ROR with IC50 of 17.6 nM. |
| PC-24711 |
ROR1 inhibitor 9i
ROR1 inhibitor
|
ROR1 inhibitor 9i is a potent, selective inhibitor of receptor tyrosine kinase-like orphan receptor ROR1, binds the intracellular kinase domain with KD of 17.2 nM, inhibits ROR1 kinase activity with IC50 of 255 nM. |
| PC-24691 |
PSSI-51
SOCT inhibitor
|
PSSI-51 is a potent, peripheral selectice succinyl-CoA:3-ketoacid-CoA transferase (SCOT) inhibitor, inhibits peripheral tissue (i.e., muscle) SCOT activity and ketone oxidation. |
| PC-24685 |
BCX-3607
TF/FVIIa inhibitor
|
BCX-3607 is a potent, selective and orally active tissue factor/factor VIIa (TF-FVIIa) inhibitor with IC50 of 4 nM. |
| PC-24683 |
CD73-IN-1
CD73 inhibitor
|
CD73-IN-1 is a potent, selective CD73 (ecto-5'-nucleotidase) inhibitor. |
| PC-24682 |
CD73 inhibitor XC-12
CD73 inhibitor
|
CD73 inhibitor XC-12 is a potent, orally bioactive CD73 inhibitor with IC50 of 12.36 and 1.29 nM against both soluble and membrane-bound forms (hCD73). |
| PC-24677 |
GT-02216
GCase modulator
|
GT-02216 is a novel allosteric glucocerebrosidase (GCase) modulator with binding KD of 55 uM, enhances GCase activity in primary human fibroblasts, prevents Tau accumulation in GBA1WT and GBA1L444P/L444P cellular models. |
| PC-24676 |
Limocitrin
CAS 489-33-8
|
Limocitrin is a natural hydroxyflavan with anticancer activity against breast cancer and NK leukemia cell lines, induceds cellular death through ERK pathways in human oral squamous cell cancer. |
| PC-24670 |
PF-07853578
PNPLA3 I148M degrader
|
PF-07853578 is a covalent inhibitor of patatin-like phospholipase domain-containing protein 3 single nucleotide polymorphism rs738409 148M (PNPLA3-148M), induces PNPLA3 degradation with EC50 of 8 nM. |
| PC-24661 |
Core Circadian Modulator
BMAL1 ligand
|
Core Circadian Modulator (CCM) is specific small molecule BMAL1 ligand, targets the cavity in the PASB domain of BMAL1 with ITC Kd of 1.99 uM, modulates BMAL1–CLOCK target gene expressions. |
