| Cat. No. |
Product Name |
Information |
| PC-24611 |
CVB4-57
Cx26 hemichannels inhibitor
|
CVB4-57 is a specific, reversible small molecule Connexin26 hemichannel (Cx26 hemichannel), reversibly inhibited the dye uptake at 5 uM without affecting the gap junction communication and barrier function. |
| PC-24605 |
Concanavalin A
Liver injury inducer
|
Concanavalin A is a Ca2+/Mn2+-dependent and mannose/glucose-binding plant lectin, can induce programmed cell death and acute liver injury. |
| PC-24596 |
SALL4 inhibitor SH6
SALL4 degrader
|
SALL4 inhibitor SH6 is a small molecule inhibitor of transcription factor SALL4 ZFC4 domain, selectively targets SALL4-expressing cancer cells (EC50=0.5 uM, SNU398 cells), degrades SALL4 protein through the CUL4A/CRBN pathway. |
| PC-24578 |
TrpGc
HINT1 inhibitor
|
TrpGc (Tryptamine guanosine carbamate) is a pharmacologically active histidine triad nucleotide-binding protein (HINT1) inhibitor with Kd of 3.65 uM, IC50 of 9.1 uM. |
| PC-24577 |
MBLAC2 inhibitor KV-79
MBLAC2 inhibitor
|
MBLAC2 inhibitor KV-79 is a potent, specific inhibitor of the metalloenzyme MBLAC2 (Metallo-Beta-Lactamase Domain Containing 2) with EC50 of 24 nM, >60 fold selectivity over HDAC6. |
| PC-24576 |
MBLAC2 inhibitor KV-65
MBLAC2 inhibitor
|
MBLAC2 inhibitor KV-65 is a potent, specific inhibitor of the metalloenzyme MBLAC2 (Metallo-Beta-Lactamase Domain Containing 2) with EC50 of 37 nM, 64-fold selectivity over HDAC6. |
| PC-24553 |
FGH10019
SREBP inhibitor
|
FGH10019 is a specific small molecule inhibitor of sterol regulatory element-binding protein (SREBP) with IC50 of 0.7 uM in SREBP-responsive reporter gene assays. |
| PC-24547 |
Fascin inhibitor G2
Fascin inhibitor
|
Fascin inhibitor G2 is a small molecule inhibitor of Fascin (FSCN1), inhibits the actin-bundling function of fascin with IC50 of 5-8 uM, blocks tumour invasion and metastatic colonization. |
| PC-24546 |
NP-G2-029
Fascin inhibitor
|
Fascin inhibitor G2 (NP-G2-029) is a specific small molecule inhibitor of Fascin (FSCN1) with IC50 of 0.19 uM in F-actin-bundling assay. |
| PC-24544 |
Z1362873773
Fascin inhibitor
|
Z1362873773 is a novel small molecule inhibitor of Fascin (FSCN1), reduces the fascin bundling activity. |
| PC-24532 |
DDL-357
Secreted clusterin enhancer
|
DDL-357 is a small molecule secreted isoform of clusterin (sCLU) enhancer with EC50 of 223 nM, increases brain sCLU in the murine ApoE4TR-5XFAD model of AD. |
| PC-24529 |
NUV-244
PNPLA3 I148M degrader
|
NUV-244 is a potent, specific small molecule degrader of PNPLA3 I148M variant, degrades PNPLA3 I148M via the ubiquitin-proteasome system and involving the E3 ligase BFAR. |
