| Cat. No. |
Product Name |
Information |
| PC-25725 |
PYCR1-IN-1
PYCR1 inhibitor
|
PYCR1-IN-1 (ProPI-1, Proline Production Inhibitor-1) is a small molecule pyrroline-5-carboxylate reductase 1 (PYCR1) inhihibitor with IC50 of 8.8 uM. |
| PC-25712 |
RWT9996
GPR17 antagonist
|
RWT9996 is a potent, selective GPR17 antagonist, inhibits both G protein activation and β-arrestin-2 recruitment. |
| PC-25706 |
hCES2A inhibitor C3
hCES2A inhibitor
|
hCES2A inhibitor C3 is a highly potent, orally active and serine-targeting covalent inhibitor of hCES2A (human carboxylesterase 2A) with IC50 of 0.56 nM, Ki of 1.58 nM. |
| PC-25702 |
ARN14686
NAAA probe
|
ARN14686 is a click chemistry activity-based probe (CC-ABP) that selectively recognizes the enzyme N-acylethanolamine acid amidase (NAAA). |
| PC-25694 |
Auxurea A
GH3 inhibitor
|
Auxurea A is a selective competitive small molecule inhibitor of IAA-amino acid conjugating enzymes GH3, specifically inhibited GH3-mediated IAA inactivation both in vivo and in vitro, induces high-auxin phenotypes in Arabidopsis. |
| PC-25661 |
TDRL-505
RPA inhibitor
|
TDRL-505 is a small molecule inhibitor of Replication protein A (RPA) with IC50 of 13 uM, inhibits RPA's DNA binding activity targeting DBD-A and B in the 70 kDa subunit of RPA. |
| PC-25635 |
TTZ-2
zDHHC2 inhibitor
|
TTZ-2 (zDHHC2 inhibitor TTZ2) is a specific enzymatic inhibitor of ZDHHC2, inhibits human zDHHC2-mediated substrate (SNAP25) S-acylation in vitro with IC50 of 1.3 uM. |
| PC-25612 |
W478
SHMT2 inhibitor
|
W478 is a potent novel serine hydroxymethyltransferase 2 (SHMT2) inhibitor with IC50 of 1.21 uM, binds to SHMT2 with ITC KD of 10.6 uM. |
| PC-25596 |
T2M-010
TREM2 agonist
|
T2M-010 is a potent small molecule binder of Triggering receptor expressed on myeloid cells 2 (TREM2) with MST KD of 0.83 uM, functions as an activator of TREM2 signaling. |
| PC-25595 |
AEPU
sEH inhibitor
|
AEPU is a moderately water soluble, orally-available, highly potent and selective soluble epoxide hydrolase (sEH) inhibitor with IC50 of 14 nM (human sEH), reduces the development of atherosclerosis in apolipoprotein e-knockout mouse model. |
| PC-25592 |
DCLK1 inhibitor 12n
DCLK1 inhibitor
|
DCLK1 inhibitor 12n is a potent, selective Doublecortin-like Kinase 1 (DCLK1) inhibitor with IC50 of 58 nM, exhibits notable DCLK1 inhibitory activity at the cellular level with IC50 of 25 nM. |
| PC-25586 |
RAGE406R
RAGE inhibitor
|
RAGE406R is a small molecule antagonist of RAGE-DIAPH1 interaction, prevents the formation of the RAGE-DIAPH1, binds to cytosolic tail of RAGE (ctRAGE) with Kd of 0.3 nM. |
