| Cat. No. |
Product Name |
Information |
| PC-25466 |
MASTL inhibitor MKI-2
Greatwall inhibitor
|
MKI-2 (MASTL kinase inhibitor-2) is a potent small molecule inhibitor of microtubule-associated serine/threonine kinase-like (MASTL, Greatwall/GWL), inhibits recombinant MASTL activity and cellular MASTL activity with IC50 of 37.44 nM and 142.7 nM, respectively. |
| PC-25450 |
RTI-19318-32
GPR3 agonist
|
RTI-19318-32 is a potent, specific full agonist of G protein-coupled receptor 3 (GPR3) with EC50 of 260 nM and Emax of 90%. |
| PC-25443 |
UCB1244283
SV2A modulator
|
UCB1244283 is a selective allosteric modulator of synaptic vesicle protein 2A (SV2A), selective over SV2B and SV2C, enhances brivaracetam (BRV) binding by occupying an allosteric site near the primary binding site, preventing BRV dissociation. |
| PC-25442 |
UCB7361
SV2A modulator
|
UCB7361 is a selective allosteric modulator of synaptic vesicle protein 2A (SV2A). |
| PC-25437 |
EN020
TREM2 modulator
|
EN020 is a novel small molecule modulator of triggering receptor expressed on myeloid cells 2 (TREM2) with KD of 14.2 µM (MST) and 35.9 µM (SPR), significantly enhances microglial phagocytosis in BV2 cells. |
| PC-25436 |
TREM2 agonist As48
TREM2 agonist
|
TREM2 agonist As48 is a specific, small-molecule agonist of triggering receptor expressed on myeloid cells 2 (TREM2) with binding KD of 12.48 uM, capable of simultaneously inhibiting ADAM-mediated receptor sheddin, enhances microglial phagocytosis. |
| PC-25426 |
ARN398
Acid ceramidase inhibitor
|
ARN398 is a higly potent, selective inhibitor of acid ceramidase (ACDase, ASAH1) with IC50 of 7 nM and 12 nM for human and rat ACDase respectively, >100-fold selective over human thymidylate synthase (h-TS). |
| PC-25425 |
ARN14988
Acid ceramidase inhibitor
|
ARN14988 is a potent, selective inhibitor of acid ceramidase (ACDase, ASAH1) with IC50 of 12.8 nM. |
| PC-25424 |
Pepstatin A
Aspartic protease inhibitor
|
Pepstatin A (Pepstatin) is a potent, specific, orally active aspartic protease inhibitor with IC50 of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. |
| PC-25387 |
5-O-Methylvisammioside
HMGB1 inhibitor, CNT2 inhibitor
|
5-O-Methylvisammioside (5OMV) is a flavonol compound derived from the traditional Chinese medicine plant Saposhnikovia divaricat, inhibits vasospasm induced by High Mobility Group Box 1 (HMGB1) protein, also inhibits intestinal concentrative nucleoside transporter 2 (CNT2) with IC50 of 11.22 uM, inhibits intestinal purine nucleoside absorption. |
| PC-25384 |
Acid ceramidase inhibitor 43
Acid ceramidase inhibitor
|
Acid ceramidase inhibitor 43 is a potent, small molecule inhibitor of acid ceramidase (aCDase) with enzymatic pIC50 of 8.5 and cellular pIC50 of 6.8 (A375 melanoma cell). |
| PC-25357 |
Avicularin
FOXM1 inhibitor
|
Avicularin is a Chinese herbal medicine with anti-inflammatory and antioxidative effects, reduces cell viability and induces caspase-dependent apoptosis in NSCLC cells by facilitating USP7-dependent degradation of FOXM1. |
