| Cat. No. |
Product Name |
Information |
| PC-25965 |
ML194
GPR35 antagonist
|
ML194 is a potent, selective GPR35 antagonist with IC50 of 160 nM, has >57-fold selectivity over GPR55 orphan receptor. |
| PC-25962 |
CVN527
GPR6 inverse agonist
|
CVN527 is a potent and selective, brain penetrant GPR6 inverse agonist, fully inhibits GPR6 with EC50 of 39.5 nM and 34 nM for mouse and human GPR6 in functional GPR6 cAMP HTRF cell -based assays. |
| PC-25942 |
TREM-1 inhibitory peptide GF9
TREM-1 inhibitor
|
TREM-1 inhibitory peptide GF9 is a peptide inhibitor of Triggering receptor expressed on myeloid cells 1 (TREM-1), significantly inhibits pancreatic cancer progression. |
| PC-25930 |
GPR81 agonist 1
GPR81 agonist, HCAR1 agonist
|
GPR81 agonist 1 is a potent and highly selective GPR81 agonist with EC50 of 58 nM and 50 nM for human and mouse GPR81 respectively, also is an agonist-positive allosteric modulator (Ago-PAM) for HCAR1. |
| PC-25903 |
2-Bromopalmitate
Palmitoylation inhibitor
|
2-Bromopalmitate (2-Bromohexadecanoic acid, 2-Bromopalmitic acid) is a broad-spectrum palmitoylation inhibitor, inhibits ZDHHC11-mediated palmitoylation, inhibits palmitoylation of GSDME-C during pyroptosis and inhibits BAK/BAX-Caspase 3-GSDME pathway-mediated pyroptosis. |
| PC-25886 |
Them1 inhibitor Compound U11
Them1 inhibitor
|
Them1 inhibitor Compound U11 is a small molecule inhibitor of thioesterase superfamily member 1 (Them1) with IC50 of 3.63 uM, selectively inhibits Them1 by binding the START domain (Kd=0.67 uM). |
| PC-25885 |
Them1 inhibitor Compound U1
Them1 inhibitor
|
Them1 inhibitor Compound U1 is a small molecule inhibitor of thioesterase superfamily member 1 (Them1) with IC50 of 8.64 uM, selectively inhibits Them1 by binding the START domain (Kd=5.97 uM). |
| PC-25882 |
PPTD free base
ZIP14 inhibitor
|
PPTD free base is the first selective small-molecule inhibitor of membrane-bound metal transporter ZIP14/SLC39A14, efficiently blocks ZIP14-mediated uptake of zinc, iron, manganese and cadmium, while sparing the closely related transporter ZIP8/SLC39A8. |
| PC-25881 |
ZIP14 inhibitor PPTD
ZIP14 inhibitor
|
ZIP14 inhibitor PPTD is the first selective small-molecule inhibitor of membrane-bound metal transporter ZIP14/SLC39A14, efficiently blocks ZIP14-mediated uptake of zinc, iron, manganese and cadmium, while sparing the closely related transporter ZIP8/SLC39A8. |
| PC-25859 |
Lysosome inhibitor LLAD
SLC38A9 inhibitor
|
LLAD is a long-term lysosome-targeting anticancer drug, inhibits SLC38A9 in lysosomes and alkalinizes lysosomes, induces apoptosis through long-term lysosomal damage in vivo and in vitro. |
| PC-25857 |
PF-429242 dihydrochloride
S1P inhibitor
|
PF-429242 dihydrochloride (PF429242) is a potent, selective, reversible and competitive inhibitor of proprotein convertase SREBP site 1 protease (S1P, Subtilisin kexin isozyme-1/SKI-1, MBTPS1) with IC50 of 170 nM. |
| PC-25841 |
3-Nitrooxypropanol
MCR inhibitor
|
3-Nitrooxypropanol (Abrucomstat, 3-NOP) is a small molecule inhibitor of methane formation in the rumen, specifically inhibits methyl-coenzyme M reductase (MCR), inhibit methanogenesis, in vitro and in vivo. |
