| Cat. No. |
Product Name |
Information |
| PC-27201 |
KK023-N1
Striga germination inhibitor, ShHTL7 inhibitor
|
KK023-N1 is a potent, specific Striga germination inhibitor, blocks the hydrolysis activity of S. hermonthica HYPO-SENSITIVE TO LIGHT 7 (ShHTL7) with IC50 of 1.78 uM, does not affect rice (Oryza sativa) SL receptor DWARF14 (OsD14). |
| PC-27135 |
Galinex
GPR17 agonist
|
Galinex is a highly potent, selective GPR17 agonist with EC50 of 0.64 nM, Emax=127.8% in [35S]GTPγS functional assays in membranes from 1321N1 cells transfected with human GPR17. |
| PC-27133 |
PT-13
Tau disaggregant
|
PT-13 is a brain-penetrant small-molecule tau disaggregant inhibiting tau seeding and disaggregating fibrils, reduces tau pathology while preserving behavioral function, proteasome capacity, and synaptic integrity in tauopathy mouse model. |
| PC-27105 |
A2ti-1
S100A10-ANXA2 inhibitor
|
A2ti-1 (S100A10-ANXA2 heterotetramer inhibitor-1) is a specific small molecule Annexin A2 (ANXA2) inhibitor, inhibits Annexin A2-S100A10 protein interaction with IC50 of 24 uM (Annexin A2/S100A10 heterotetramer (A2t)). |
| PC-27102 |
TRMT10C agonist TM3
TRMT10C agonist
|
TRMT10C agonist TM3 is a small molecule agonist of tRNA methyltransferase 10C (TRMT10C), exhibits direct binding with a dissociation constant (Kd) of 2.6 uM in SPR assays, promotes osteoblast differentiation and protects against osteoporosis. |
| PC-27087 |
S428-1145
PUS7 inhibitor
|
S428-1145 is a small molecule inhibitor targeting pseudouridine synthase 7 (PUS7), has anti-proliferative IC50 of 20 µM in MIA PaCa-2 cells and 20.68 µM in PANC-1 cells, respectively, significantly inhibits tumour growth. |
| PC-27049 |
SB-583355
GPR132 antagonist
|
SB-583355 is a potent, peptidomimetic inhibitor of GPR132 (G2A), inhibits agonist-induced hGPR132aPL association with β-arrestin with pIC50 of 7.0. |
| PC-27047 |
SKF-95667
GPR132 agonist
|
SKF-95667 is a potent, selective agonist of G-protein-coupled receptor GPR132 (G2A) with pEC50 of 6.6 and 5.8 in yeast and β-arrestin assays (human GPR132a). |
| PC-27046 |
GSK1820795A
GPR132 antagonist
|
GSK1820795A is a potent, specific antagonist of G-protein-coupled receptor GPR132 (G2A), blocks agonist-induced association of hGPR132 with β-arrestin with pIC50 of 7.8, also is a dual angiotensin AT1 antagonist and PPARγ modulator. |
| PC-26951 |
AGPS-IN-1
AGPS inhibitor
|
AGPS-IN-1 (AGPS inhibitor 2i) is a small molecule inhibitor of alkylglyceronephosphate synthase (AGPS), decreases ether lipids, cell migration and survival, specifically impairs EMT through E-cadherine, Snail, Mmp2 modulation. |
| PC-26936 |
NCGC00685960
NNMT inhibitor
|
NCGC00685960 is a highly potent, specific Nicotinamide N-methyltransferase (NNMT) inhibitor with IC50 of <10 nM, increases H3K27 trimethylation levels in ovarian cancer cells and inhibits α-SMA expression in NNMT-expressing ovarian fibroblasts, has potent antitumor activity. |
| PC-26922 |
GPR52 agonist R-185
GPR52 agonist
|
GPR52 agonist R-185 is a potent, selective, brain permeable and orally available GPR52 agonist with EC50 of 26 nM, significantly inhibits MK-801-induced hyperlocomotor behaviors in zebrafish larvae and mice. |
