| Cat. No. |
Product Name |
Information |
| PC-27381 |
CC-156
HSD17B1 inhibitor
|
CC-156 is a potent, selective 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1, HSD17B1) with IC50 of 44 nM. |
| PC-27367 |
CN045
OPC differentiation stimulator
|
CN045 is a brain-penetrable enhancer of oligodendrocyte progenitor cells (OPCs) differentiation and remyelination, stimulates differentiation of mouse OPCs into oligodendrocytes with EC50 of 40 nM in the OPC differentiation assay. |
| PC-27358 |
Pyripyropene A
ACAT2 inhibitor
|
Pyripyropene A (Pyri-A, PPPA) is a highly potent and selective inhibitor of acyl CoA:cholesterol acyltransferase 2 (ACAT2, Sterol O-acyltransferase 2, SOAT2) with IC50 of 70 nM, >1000-fold selective over SOAT1/ACAT1. |
| PC-27357 |
DHODH inhibitor HL6
DHODH inhibitor
|
DHODH inhibitor HL6 is a potent, CoQ-competitive DHODH inhibitor with Ki of 2.39 nMand IC50 of 5.29 nM (recombinant human DHODH), disrupts WDR77 stabilization, thereby attenuating PRMT5/WDR77-dependent AKT signaling in PIK3CA-mutant CRC. |
| PC-27356 |
Hesperetin
520-33-2
|
Hesperidin (Hesperetin 7-rutinoside) is a flavanone glycoside isolated from citrus fruits, shows numerous biological properties, such as decreasing inflammatory mediators and exerting significant antioxidant effects, antitumor and antiallergic activities. |
| PC-27355 |
KY-455
ACAT inhibitor
|
KY-455 is an anti-oxidative ACAT inhibitor, inhibits rabbit intestinal, hepatic, macrophage and adrenal ACAT with IC50 of 0.4, 0.9, 2.9 and 4.1 uM, respectively. |
| PC-27348 |
ST029248
Mast cell activator
|
ST029248 is a small molecule mast cell activator (MCA) with 50% degranulation levels (MCD50) of 2.9 uM, promotes de novo synthesis of cytokines and induce the release of eicosanoids from MCs. |
| PC-27347 |
ST026567
Mast cell activator
|
ST026567 is a small molecule mast cell activator (MCA), induces mouse BMMCs degranulation achieving 50% degranulation levels (MCD50) of 24.6 uM, promotes de novo synthesis of cytokines and induce the release of eicosanoids from MCs. |
| PC-27346 |
VAP-1185
Mast cell activator
|
VAP-1185 is a potent small molecule mast cell activator (MCA), induces mouse BMMCs degranulation, promotes a Th1-biased immune response when combined with TLR9 agonist CpG. |
| PC-27345 |
ST101036
Mast cell activator
|
ST101036 is a small molecule mast cell activator (MCA), induces mouse BMMCs degranulation about 91% at 100 uM, and 38% in human LAD2 cells, promotes de novo synthesis of cytokines and induce the release of eicosanoids from mouse MCs. |
| PC-27344 |
OGG1 agonist F01
OGG1 agonist
|
OGG1 agonist F01 is a potent small-molecule agonist with EC50 of 9.1 uM with 8-oxoGua-containing DNA substrate. |
| PC-27343 |
OGG1 agonist F51
OGG1 agonist
|
OGG1 agonist F51 is a potent small-molecule agonist, protects against PQ-induced cytotoxicity in Kasumi-1 cells, binds to catalytic-site rather than allosteric binding. |
