| Cat. No. |
Product Name |
Information |
| PC-26835 |
PGK1 activator L03
PGK1 activator
|
PGK1 activator L03 (AT-051/43421517) is a specific small molecule activator of phosphoglycerate kinase 1 (PGK1) with SPR KD of 2.45 uM, significantly enhances enzymatic activity of PGK1 at 0.25-2 uM in AβO-induced SH-SY5Y cells. |
| PC-26830 |
MOXD1 inhibitor rM15
MOXD1 inhibitor
|
MOXD1 inhibitor rM15 is a small molecule of monooxygenase DBH like 1 (MOXD1) inhibitor, directly binds to MOXD1 and blocks its interaction with ACOX1, protects against hepatocyte lipid accumulation and suppressed diet-induced MASH progression. |
| PC-26826 |
Cetrimonium bromide
EBNA1 inhibitor
|
Cetrimonium bromide (CetB) is a specific small-molecule inhibitor of Epstein-Barr virus (EBV) latently infected cancer cells, reduces EBNA1 protein stability, activates G1 arrest and early apoptosis of EBV-latently infected cells without viral lytic reactivation, modulates canonical and non-canonical TGF-β signaling pathways, inhibits cancer cell migration and invasion. |
| PC-26823 |
KG-296
CLOCK/NPAS2 PAS-A inhibitor
|
KG-296 is a small molecule ligand that bind to the PAS-A domain of NPAS2 and its paralog CLOCK, binds to CLOCK PAS-A with Kd of 120 uM, specifically binds to CLOCK/NPAS2 PAS-A domains, inhibits DNA binding to CLOCK:BMAL1. |
| PC-26819 |
Myricoside
B4GALT3 inhibitor
|
Myricoside is a phenylethanoid triglycoside from Phlomis oppositiflora and small molecule β‑1,4‑galactosyltransferase III (B4GALT3) inhibitor. |
| PC-26815 |
Acarbose
alpha-glucosidase inhibitor
|
Acarbose (BAY g 5421) is an antihyperglycemic agent and orally active alpha-glucosidase (α-glucosidase) inhibitor with IC50 of 11 nM, potentiates the hypoglycemic effects of sulfonylureas or insulin. |
| PC-26814 |
HMGCS1 inhibitor CNP7
HMGCS1 inhibitor
|
CNP7 is a potent, selective, covalent HMG-CoA synthase 1 (HMGCS1) inhibitor, reduces HMG-CoA levels and global protein prenylation. |
| PC-26812 |
BI-0115
LOX-1 inhibitor
|
BI-0115 is a selective small molecule inhibitor of lectin-like oxidized LDL receptor-1 (LOX-1) with IC50 of 5.4 uM, blocks cellular uptake of oxidized low-density lipoproteins (oxLDL). |
| PC-26802 |
CNT2198
DES1 inhibitor
|
CNT2198 is a potent, selective dihydroceramide desaturase 1 (DES1) inhibitor, lowers renal ceramides, increases dihydroceramides, and shifts complex sphingolipid saturation without evidence of off-target effects. |
| PC-26799 |
XM462
Dihydroceramide desaturase inhibitor
|
XM462 is a small molecule inhibitor of dihydroceramide desaturase (Des1) with IC50 of 8.2 uM and Ki of 2 uM, inhibits sphingolipid synthesis, triggers autophagy and reduces amyloid secretion by neurons. |
| PC-26798 |
Des 1 inhibitor GT11
Des1 inhibitor
|
Des 1 inhibitor GT11 ((1R,2S)-Deoxy-PR280) is a competitive inhibitor of dihydroceramide desaturase with Ki of 6 uM, induces Des1 inhibition in rat liver microsomes with IC50 of 20 uM. |
| PC-26797 |
PR280
Des1 inhibitor
|
PR280 is a potent small molecule inhibitor of dihydroceramide desaturase 1 (Des1) with IC50 of 700 nM. |
