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首页-小分子抑制剂&激动剂-Others-Other Targets-(S)-Retro-2.1
(S)-Retro-2.1

Chemical Structure : (S)-Retro-2.1

CAS No.: 1510796-68-5

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(S)-Retro-2.1 (Retro-2.1a)

货号: PC-27431Not For Human Use, Lab Use Only.

Retro-2.1a ((S)-Retro-2.1) is a potent molecule to counteract the cytotoxic potential of ricin and Shiga toxin with EC50 of 23 nM and 54 nM, respectively, blocking retrograde transport and intracellular retrograde trafficking.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Retro-2.1a ((S)-Retro-2.1) is a potent molecule to counteract the cytotoxic potential of ricin and Shiga toxin with EC50 of 23 nM and 54 nM, respectively, blocking retrograde transport and intracellular retrograde trafficking.

物理化学性质&存储条件

分子量 435.54
分子式 C23H18FN3OS2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-6-fluoro-1-methyl-2-(5-(2-methylthiazol-4-yl)thiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one

参考文献

1. Gupta N, et al. ACS Med Chem Lett. 2013 Dec 4;5(1):94-7.

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