FSG67 | GPAT inhibitor | Probechem Biochemicals

Chemical Structure : FSG67

CAS No.: 1158383-34-6

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FSG67 (FSG-67)

货号: PC-27442Not For Human Use, Lab Use Only.

FSG67 is a small molecule mitochondrial glycerol-3-phosphate acyltransferase (mitochondrial GPAT, GPAM) inhibitor with IC50 30.2 μM for total mitochondrial GPAT and 42.1 μM for GPAT1.

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5 mg	￥1980	In stock
10 mg	￥3280	In stock
25 mg	￥5280	In stock
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100 mg		Get quote

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生物&药学活性

FSG67 is a small molecule mitochondrial glycerol-3-phosphate acyltransferase (mitochondrial GPAT, GPAM) inhibitor with IC50 30.2 μM for total mitochondrial GPAT and 42.1 μM for GPAT1.
FSG67 reduces acylglyceride synthesis in 3T3-L1 adipocytes, has IC50 of 33.9 μM for cellular triglyceride synthesis and 36.3 μM for phosphatidylcholine synthesis.
Acute FSG67 treatment (20 mg/kg ip) produces weight loss and decreases food consumption in lean and DIO mice.
Chronic FSG67 decreases the size of white adipocytes and resolves hepatic steatosis in DIO mice, reduces food consumption and body weight.
FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling.

物理化学性质&存储条件

分子量	327.44
分子式	C16H25NO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(Nonylsulfonamido)benzoic acid

参考文献

1. Clemens MM, et al. Food Chem Toxicol. 2019 Mar;125:279-288.

2. Kuhajda FP, et al. Am J Physiol Regul Integr Comp Physiol. 2011 Jul;301(1):R116-30.

3. Irifune H, et al. Cancer Sci. 2023 Aug;114(8):3247-3258.

FSG67 (FSG-67)

生物&药学活性

物理化学性质&存储条件

参考文献

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FSG67 (FSG-67)

生物&药学活性

物理化学性质&存储条件

参考文献

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