Retro-2 cycl | Retrograde transport inhibitor | Probechem Biochemicals

Chemical Structure : Retro-2 cycl

CAS No.: 1429192-00-6

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Retro-2 cycl (Retro-2 (cycl), RN 1-001)

货号: PC-27432Not For Human Use, Lab Use Only.

Retro-2(cycl) (Retro-2 cycl) is a small molecule inhibitor of host retrograde trafficking, inhibits ricin and Shiga-like toxins (SLTs), inhibits infection by JCPyV, BKPyV, and simian virus 40 (SV40).

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg		Get quote

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生物&药学活性

Retro-2(cycl) (Retro-2 cycl) is a small molecule inhibitor of host retrograde trafficking, inhibits ricin and Shiga-like toxins (SLTs), inhibits infection by JCPyV, BKPyV, and simian virus 40 (SV40).
Retro-2(cycl) inhibits retrograde transport of polyomaviruses to the endoplasmic reticulum.
Retro-2(cycl) likely inhibits polyomaviruses in a way similar to its ricin and SLT inhibition, suggesting an overlap in the cellular host factors used by bacterial toxins and polyomaviruses.
Retro-2(cycl) protects cells from infection with JCPyV and BKPyV by inhibiting intracellular viral transport.
Retro-2(cycl) significantly reduced body weight loss and improved clinical scores and survival rates for O104:H4-infected mice.

物理化学性质&存储条件

分子量	320.41
分子式	C19H16N2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5-Methylthiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one

参考文献

1. Secher T, et al. Antimicrob Agents Chemother. 2015 Aug;59(8):5010-3.

2. Carney DW, et al. Bioorg Med Chem. 2014 Sep 1;22(17):4836-47.

3. Nelson CD, et al. mBio. 2013 Nov 12;4(6):e00729-13.

4. Yu S, et al. Sci Rep. 2013 Dec 2;3:3397.

Retro-2 cycl (Retro-2 (cycl), RN 1-001)

生物&药学活性

物理化学性质&存储条件

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Retro-2 cycl (Retro-2 (cycl), RN 1-001)

生物&药学活性

物理化学性质&存储条件

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