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首页-小分子抑制剂&激动剂-Others-Other Targets-Retro-2.1
Retro-2.1

Chemical Structure : Retro-2.1

CAS No.: 1510796-66-3

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Retro-2.1

货号: PC-27430Not For Human Use, Lab Use Only.

Retro-2.1 is a small molecule inhibitor of retrograde transport, protects human cells against ricin and Stx by blocking retrograde toxin transport at the early endosomes-TGN interface, efficiently inhibits SARS-CoV-2 replication, inhibits JC polyomavirus (JCPyV) with EC50 of 3.9 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Retro-2.1 is a small molecule inhibitor of retrograde transport, protects human cells against ricin and Stx by blocking retrograde toxin transport at the early endosomes-TGN interface, efficiently inhibits SARS-CoV-2 replication, inhibits JC polyomavirus (JCPyV) with EC50 of 3.9 uM.

物理化学性质&存储条件

分子量 435.54
分子式 C23H18FN3OS2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-fluoro-1-methyl-2-(5-(2-methylthiazol-4-yl)thiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one

参考文献

1. Vinck R, et al. Int J Mol Sci. 2022 Nov 23;23(23):14611.

2. Holwerda M, et al. Microorganisms. 2020 Nov 26;8(12):1872.

3. Gupta N, et al. ACS Med Chem Lett. 2013 Dec 4;5(1):94-7.

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