RJG-2036 | PTGR2 inhibitor | Probechem Biochemicals

Chemical Structure : RJG-2036

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RJG-2036 (RJG2036)

货号: PC-24626Not For Human Use, Lab Use Only.

RJG-2036 is a potent, selective, covalent prostaglandin reductase 2 (PTGR2) inhibitor with IC50 of 100 nM (human PTGR2), covalently ligands the noncatalytic Y100 and Y265 residues located in the substrate binding pocket.

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生物&药学活性

RJG-2036 is a potent, selective, covalent prostaglandin reductase 2 (PTGR2) inhibitor with IC50 of 100 nM (human PTGR2), covalently ligands the noncatalytic Y100 and Y265 residues located in the substrate binding pocket.
RJG-2036 blocks recombinant PTGR2 biochemical activity with IC50 of 176 nM.
RJG-2036 ligands the noncatalytic Y100 and Y265 sites on PTGR2.
RJG-2036 (10 uM) suppresses LPS-stimulated TNF-α response in THP1 macrophages, alters the activity of PTGR2-regulated eicosanoids.

物理化学性质&存储条件

分子量	427.48
分子式	C20H21N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-((1H-1,2,4-triazol-1-yl)sulfonyl)phenyl)(4-(2-methoxyphenyl)piperazin-1-yl)methanone

参考文献

1. Founds MW, et al. ACS Chem Biol. 2025 May 19. doi: 10.1021/acschembio.5c00231.

RJG-2036 (RJG2036)

生物&药学活性

物理化学性质&存储条件

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RJG-2036 (RJG2036)

生物&药学活性

物理化学性质&存储条件

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