Cucurbitacin B | IGF2BP1 inhibitor | Probechem Biochemicals

Chemical Structure : Cucurbitacin B

CAS No.: 6199-67-3

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Cucurbitacin B ((+)-Cucurbitacin B)

货号: PC-24650Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

Cucurbitacin B (CuB) is a potent but toxic anticancer natural product, an irreversible covalent inhibitor of IGF2BP1 and forms a covalent bond with cysteine 253 of the IGF2BP1 KH 1-2 domain (KD=66.8 nM).
Cucurbitacin B inhibits the proliferation of various tumors in vitro and in vivo, including liver cancer, breast cancer, myeloid leukemia, renal cell carcinoma, prostate cancer, non-small cell lung cancer (NSCLC).
Cucurbitacin B destabilizes IGF2BP1-regulated target mRNA and induces tumor cell apoptosis, which in turn attracts immune cells to the tumor microenvironment.

物理化学性质&存储条件

分子量	558.71
分子式	C32H46O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R,E)-6-((2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate

参考文献

1. Liu Yang, et al. ACS Central Science (2022), 8 (8), 1102-1115.

2. Shang FF, et al. J Med Chem. 2023 Sep 28;66(18):12931-12949.

Cucurbitacin B ((+)-Cucurbitacin B)

生物&药学活性

物理化学性质&存储条件

参考文献

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Cucurbitacin B ((+)-Cucurbitacin B)

生物&药学活性

物理化学性质&存储条件

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