Necrocide 1 (NC1)

Chemical Structure : Necrocide 1

CAS No.: 1247028-61-0

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货号: PC-23519Not For Human Use, Lab Use Only.

Necrocide 1 (NC1) is a small molecule inducer of tumor necrosis factor (TNF)-independent necrosis, shows antiproliferative activity with IC50 values of 0.48 and 2 nM for MCF-7 and PC3, respectively.

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5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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生物&药学活性

Necrocide 1 (NC1) is a small molecule inducer of tumor necrosis factor (TNF)-independent necrosis, shows antiproliferative activity with IC50 values of 0.48 and 2 nM for MCF-7 and PC3, respectively.
Necrocide 1 (NC1) targets TRPM4 to promote Na+ influx and necrosis.
Necrocide 1 specifically activates human TRPM4, not mouse TRPM4.
Necrocide 1 (NC1) induces necrotic cell death through sodium overload (NECSO).

物理化学性质&存储条件

分子量	365.47
分子式	C23H27NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2H-Indol-2-one, 3-cycloheptyl-1,3-dihydro-3-(4-hydroxyphenyl)-6-Methoxy-7-Methyl-, (3S)-

参考文献

1. Jing Zhang, et al. Cell Death Dis. 2023 Apr 5;14(4):238.
2, Fu W, et al. Nat Chem Biol. 2025 Feb 6. doi: 10.1038/s41589-025-01841-3.

Necrocide 1 (NC1)

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