Greatwall inhibitor C-604 | Greatwall inhibitor | Probechem Biochemicals

Chemical Structure : Greatwall inhibitor C-604

加入收藏

Greatwall inhibitor C-604 (UOS-00054604)

货号: PC-25465Not For Human Use, Lab Use Only.

Greatwall inhibitor C-604 (UOS-00054604) is a potent, highly selective Greatwall kinase (GWL, MASTL) inhibitor with IC50 of 9 nM in HTRF assays.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Greatwall inhibitor C-604 (UOS-00054604) is a potent, highly selective Greatwall kinase (GWL, MASTL) inhibitor with IC50 of 9 nM in HTRF assays.
C-604 inhibits GWL in a non-stereospecific manner.
C-604 treatment (0-4 uM) resulted in gradual dephosphorylation of ENSA(S67) and ARPP19(S62) in prometaphase-arrested HCC1395 (breast cancer), U2OS (osteosarcoma), RPE-1 (non-transformed) and HeLa (cervical cancer) cells.
C-604 (2 uM) demonstrates strong cytostatic properties, effectively inhibiting colony formation in RPE-1 and HeLa cells exposed to the compound for 72 h.
C-604 causes pleiotropic B55α-dependent cellular pathologies, acts on-target and interferes with the PP2A-B55/ENSA/GWL regulatory axis.

物理化学性质&存储条件

分子量	441.54
分子式	C26H27N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-methyl-2-(4-(2-(3-phenylpyrrolidin-1-yl)ethoxy)phenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

参考文献

1. Zach R, et al. Nat Commun. 2025 Aug 27;16(1):8016.

Greatwall inhibitor C-604 (UOS-00054604)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Greatwall inhibitor C-604 (UOS-00054604)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.