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首页-小分子抑制剂&激动剂-Others-Other Targets-RGX-202
RGX-202

Chemical Structure : RGX-202

CAS No.: 353-09-3

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RGX-202 (RGX202, Ompenaclid, 3-Guanidinopropionic acid, β-guanidinoproprionic acid)

货号: PC-25445Not For Human Use, Lab Use Only.

RGX-202 (RGX202, Ompenaclid, β-guanidinoproprionic acid) is an oral small-molecule creatine mimetic inhibitor of creatine transporter SLC6A8, inhibits cellular creatine import and suppresses intracellular phosphocreatine, creatine, and ATP levels, exhibits broad antitumor activity against diverse primary and metastatic CRCs.

规格 价格 库存 数量
100 mg ￥450 In stock
500 mg ￥950 In stock
1 g ￥1350 In stock
5 g Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RGX-202 (RGX202, Ompenaclid, β-guanidinoproprionic acid) is an oral small-molecule creatine mimetic inhibitor of creatine transporter SLC6A8, inhibits cellular creatine import and suppresses intracellular phosphocreatine, creatine, and ATP levels, exhibits broad antitumor activity against diverse primary and metastatic CRCs.
RGX-202 induces apoptosis and inhibits tumor cell proliferation. inhibits growth of KRAS mutant and wild-type CRC PDXs.
RGX-202 synergizes with 5-FU and leflunomide.
RGX-202 exerts potent antitumor activity alone and in combination with lenvatinib in patient-derived xenografts and primary HCC mouse models.

物理化学性质&存储条件

分子量 131.14
分子式 C4H9N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Guanidinopropanoic acid

参考文献

1. Kurth I, et al. Sci Adv. 2021 Oct 8;7(41):eabi7511.

2. Li RZ, et al. Cancer Res. 2025 Jul 31. doi: 10.1158/0008-5472.CAN-25-0301.

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