G4451 | GPR31 inhibitor | Probechem Biochemicals

Chemical Structure : G4451

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G4451 (G-4451)

货号: PC-25446Not For Human Use, Lab Use Only.

G4451 is a specific small molecule inhibitor of GPR31, inhibits the GPR31-Gαi3 interaction by targeting the GPR31 conformational transition, effectively blocked MASH progression.

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生物&药学活性

G4451 is a specific small molecule inhibitor of GPR31, inhibits the GPR31-Gαi3 interaction by targeting the GPR31 conformational transition, effectively blocked MASH progression.
G4451 shows robust inhibitory effects on lipid accumulation, inflammatory response, and MAPK signaling upon PA/OA treatment in primary hepatocytes.
G4451-mediated inhibitory effects were dependent on GPR31 expression.
G4451 (60 mg/kg, or 10 mg/kg/d, orally) effectively blocked metabolic dysfunction–associated steatohepatitis (MASH) in mice and monkeys, greatly suppressed MASH-related genes.

物理化学性质&存储条件

分子量	593.65
分子式	C32H34F3N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-benzamido-2-(piperidine-1-carbonyl)phenyl)-N-(3-(trifluoromethyl)phenyl)-1,4-diazepane-1-carboxamide

参考文献

1. Zhang XJ, et al. J Clin Invest. 2025 Sep 2;135(17):e173193.

G4451 (G-4451)

生物&药学活性

物理化学性质&存储条件

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G4451 (G-4451)

生物&药学活性

物理化学性质&存储条件

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