MSC778 | FEN1 inhibitor | Probechem Biochemicals

Chemical Structure : MSC778

加入收藏

MSC778 (MSC-778)

货号: PC-25526Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

MSC778 (MSC-778) is a potent, selective, and orally bioavailable inhibitor of Flap endonuclease 1 (FEN1) with IC50 of 3.0 nM and SPR KD of 2.9 nM, >65-fold selective over closely related RAD2 family members EXO1, GEN1 and XPG.
MSC778 displays potent cell target engagement of FEN1 in NanoBRET assays with EC50 of 31 nM.
MSC778 demonstrates a BRCA2-selective phenotype, preferentially killing BRCA2 KO DLD-1 colorectal cancer cells, with a 10-fold margin over WT DLD-1.
MSC778 displays excellent selectivity against all members of an in-house panel of the broader nuclease superfamily, with MRE11 being the next closest in activity (>1000-fold selectivity).
MSC778 potentiates the activity of PARPi niraparib in vivo to induce tumor stasis in a BRCA2 KO DLD-1 mouse xenograft.

物理化学性质&存储条件

分子量	441.87
分子式	C22H20ClN3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-((S)-1-(7-Chloronaphthalen-2-yl)ethoxy)-4-hydroxy-7,8,10a,11-tetrahydro-10H-pyridazino[1′,6′:4,5]pyrazino[2,1-c][1,4]oxazine-3,5-dione

参考文献

1. Mann SE, et al. J Med Chem. 2025 Sep 17. doi: 10.1021/acs.jmedchem.5c01526.

MSC778 (MSC-778)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

MSC778 (MSC-778)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.