| Cat. No. |
Product Name |
Information |
| PC-28604 |
Z247611722
Serine palmitoyltransferase inhibitor, Antifungal
|
Z247611722 is a novel antifungal, inhibitor of sphingolipid biosynthesis and serine palmitoyltransferase (SPT), displays fungicidal activity against multiple Candida species (C. albicans, MIC=1.56 uM) and fluconazole-resistant isolates. |
| PC-28566 |
D-e-MAPP
Ceramidase inhibitor
|
D-e-MAPP (D-erythro-MAPP) is a ceramide analogue and specific inhibitor of alkaline ceramidase, inhibits alkaline ceramidase activity in vitro with IC50 of 1-5 uM. |
| PC-28550 |
Milategrast
Cell adhesion inhibitor
|
Milategrast (E6007) is a small molecule cell adhesion and cell infiltration inhibitor, inhibits the adhesion of Jurkat cells to human fibronectin with IC50 of <5 uM. |
| PC-28548 |
GR148672X
CES1 inhibitor
|
GR148672X (GR-148672X) is a specific small molecule inhibitor of Carboxylesterase 1 (CES1)/Triacylglycerol hydrolase (TGH), significantly increases glucose limitation (GL)-induced cell death in human CRC cell linees, counters CRC tumorigenesis in vivo. |
| PC-28510 |
Orniplabin
Plasminogen modulator, sEh inhibitor
|
Orniplabin (SMTP-7, Lemuplamor, Stachybotrys microspora triprenylphenol-7) is a fungal triprenyl phenol metabolite and plasminogen modulator, shows thrombolytic and anti-inflammatory effects, inhibits soluble epoxide hydrolase (sEH) to suppress inflammation, inhibits Cterm-EH and the Nterm-phos of sEH with IC50 of 23 uM and 6 uM. |
| PC-28496 |
DHPAAS inhibitor 1
Insect DHPAAS inhibitor
|
2,5,2',4'-tetrahydroxychalcone is a insect-specific inhibitor of DHPAAS 3,4-dihydroxyphenylacetaldehyde (DHPAA) synthase (DHPAAS), shows insecticide effect. |
| PC-28491 |
AKR-XI-85
RBP4 antatgonist
|
AKR-XI-85 is a potent, non-retinoid triazolopyrimidine Retinol-Binding Protein 4 (RBP4) antagonist with binding IC50 of 23 nM in SPA assay and 194 nM in TTR-RBP4 HTRF assay. |
| PC-28460 |
KPB82
ACER2 inhibitor
|
KPB82 is a potent and selective, competitive Alkaline ceramidase 2 (ACER2) inhibitor with IC50 of 190 nM, displaying minimal activity against ACER1, ACER3, ASAH1, or ASAH2. |
| PC-28457 |
ALCAT1-IN-1
ALCAT1 inhibitor
|
ALCAT1-IN-1 (Compound 222) is a potent and highly specific acyl-coenzyme A:lysocardiolipin acyltransferase-1 (ALCAT1) inhibitor with IC50 of <15 nM. |
| PC-28453 |
NFAT inhibitor 14
NFAT inhibitor
|
NFAT inhibitor 14 is a small-molecule calcineurin-nuclear factor of activated T cells (NFAT) signaling inhibitor, inhibits the nuclear translocation and transcriptional activity of both NFATc1 and NFATc2, suppresses NFAT-dependent cytokine production, and shows cellular immunosuppressive activities. |
| PC-28436 |
A10P3C
EGLN2 inhibitor
|
A10P3C is a potent, isoform-selective inhibitor of prolyl hydroxylase EGLN2, effectively suppresses breast cancer cell proliferation, migration and invasion, induces G1 cell cycle arrest and cellular senescence through on-target EGLN2 inhibition. |
| PC-26013A |
GPR83 agonist CPD27
GPR83 agonist
|
GPR83 agonist CPD27 is a potent, selective small molecule GPR83 agonist with binding IC50 of 0.1 nM, and EC50 of 0.8 nM for [35S]GTPγS binding to membranes from CHO cells expressing mouse GPR83. |
