D-e-MAPP (D-erythro-MAPP)

Chemical Structure : D-e-MAPP

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货号: PC-28566Not For Human Use, Lab Use Only.

D-e-MAPP (D-erythro-MAPP) is a ceramide analogue and specific inhibitor of alkaline ceramidase, inhibits alkaline ceramidase activity in vitro with IC50 of 1-5 uM.

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50 mg		Get quote
100 mg		Get quote

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生物&药学活性

D-e-MAPP (D-erythro-MAPP) is a ceramide analogue and specific inhibitor of alkaline ceramidase, inhibits alkaline ceramidase activity in vitro with IC50 of 1-5 uM.
D-e-MAPP does not modulate the activity of other ceramide metabolizing enzymes in vitro or in cells, and is a poor inhibitor of acid ceramidase (IC50>500 microM).
D-e-MAPP treatment elevates endogenous levels of ceramide with the consequent biologic effects of growth suppression and cell cycle arrest in HL-60 human promyelocytic leukemia cells.
D-e-MAPP induces apoptosis and suppression of proliferation in HaCaT keratinocytes.

物理化学性质&存储条件

分子量	361.57
分子式	C23H39NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(1R,2S)-2-Hydroxy-1-methyl-2-phenylethyl]-tetradecanamide

参考文献

1. Bielawska A, et al. J Biol Chem. 1996 May 24;271(21):12646-54.

2. Raisova M, et al. FEBS Lett. 2002 Apr 10;516(1-3):47-52.