| Cat. No. |
Product Name |
Information |
| PC-27867 |
SPH7050
LANCL2 agonist
|
SPH7050 is a gut-restricted Lanthionine synthetase C-like protein 2 (LANCL2) agonist, binds LANCL2 with SPR KD of 2.73 uM, inhibits prostaglandin E2 (PGE2) production in bone marrow-derived macrophages (BMDMs) with IC50 of 0.85 uM. |
| PC-27863 |
AW-006
SNX10 modulator
|
AW-006 is a small-molecule modulator targeting Sorting nexin 10 (SNX10), selectively inhibiting osteoclast resorptive function while maintaining normal osteoclastogenesis in vitro. |
| PC-27846 |
S-5-oxo
PRODH inhibitor
|
S-5-oxo (S-5-oxo-2-tetrahydrofurancarboxylic acid) is a competitive inhibitor, reversible inhibitor of proline dehydrogenase (PRODH), inhibits proline oxidation in mitochondria, induces selective mitochondrial decay of PRODH. |
| PC-27843 |
MBTP-15324
PRODH inhibitor
|
MBTP-15324 is an allosteric inhibitor of proline dehydrogenase (PRODH) with Kd of 1.45 uM, significantly attenuates cell viability, colony formation, and migration in PRODH-overexpressing lung cancer cells (A549 and LLC). |
| PC-27827 |
DD1E5
DDAH1 inhibitor
|
DD1E5 is a competitive inhibitor of dimethylarginine dimethylaminohydrolase1 (DDAH1) with Ki of 2.05 uM, inhibits cancer cell proliferation and a subsequent decrease in NO production with ADMA accumulation. |
| PC-27820 |
CAD-09
Glyoxalase I inhibitor
|
CAD-09 is a caffeic acid ester derivative and potently inhibitor of human Glyoxalase I (GLO I) with IC50 of 1.3 uM (human GLO I), shows significant antiproliferative effect on HL-60 cells. |
| PC-27819 |
FZ581
sEH-P inhibitor
|
FZ581 is a potent, pan-species inhibitor of soluble epoxide hydrolase (sEH) N-terminal phosphatase domain (sEH-P, sEH NTD) with IC50 of 59 and 490 nM for human and mouse sEH NTD, shows little to no activity against full-length sEH protein (sEH FL). |
| PC-27818 |
NBCn2 inhibitor Cmpd38J
NBCn2 (SLC4A10) inhibitor
|
NBCn2 inhibitor Cmpd38J is a small molecule inhibitor of carbonate transporter NBCn2 (SLC4A10) with IC50 of 20.3 uM. |
| PC-27804 |
BSH-IN-1
BSH inhibitor
|
BSH-IN-1 is a potent and covalent inhibitor of gut bacterial bile salt hydrolases (BSHs) with IC50s of 108 nM and 427 nM for B. longum BSH (Gram positive) and B. theta BSH (Gram negative), respectively. |
| PC-27803 |
BSH inhibitor GR-7
BSH inhibitor
|
BSH inhibitor GR-7 (Gut restricted-7) is a potent, specific, covalent inhibitor of gut bacterial bile salt hydrolase (BSH) with IC50 of 237-1070 nM. |
| PC-27800 |
SMALS-329
LKB1 activator
|
SMALS-329 is a small-molecule activator of liver kinase B1 (LKB1, STK11) via pseudokinase STE20-related kinase adapter protein (STRAD) with EC50 of 8.5 uM (activation 541%), binds ATP pocket of STRADα to activate LKB1. |
| PC-27779 |
Phoenixin-14
GPR173 ligand
|
Phoenixin-14 (PNX-14) is an endogenous neuropeptide with multiple biological activities and endogenous ligand of GPR173. |
