GSK1820795A | GPR132 antagonist | Probechem Biochemicals

Chemical Structure : GSK1820795A

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GSK1820795A (GSK-1820795A)

货号: PC-27046Not For Human Use, Lab Use Only.

GSK1820795A is a potent, specific antagonist of G-protein-coupled receptor GPR132 (G2A), blocks agonist-induced association of hGPR132 with β-arrestin with pIC50 of 7.8, also is a dual angiotensin AT1 antagonist and PPARγ modulator.

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100 mg		Get quote

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生物&药学活性

GSK1820795A is a potent, specific antagonist of G-protein-coupled receptor GPR132 (G2A), blocks agonist-induced association of hGPR132 with β-arrestin with pIC50 of 7.8, also is a dual angiotensin AT1 antagonist and PPARγ modulator.
GSK1820795A does not antagonize free fatty acid receptor FFA2.
GSK1820795A blocks rGPR132.
GSK1820795A blocks activation of yeast cells expressing hGPR132a by N‐acylamides.

物理化学性质&存储条件

分子量	566.71
分子式	C35H34N8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-5-(1-butyl-1H-benzo[d]imidazol-2-yl)-2-propyl-2H-indazole

参考文献

1. Foster JR, et al. Pharmacol Res Perspect. 2019;7(6):e00542.

2. James R Foster, et al. Pharmacol Res Perspect. 2019 Nov 21;7(6):e00542.

3. Lamotte Y, F, et al. Bioorg Med Chem Lett. 2014;24(4):1098-1103.

GSK1820795A (GSK-1820795A)

生物&药学活性

物理化学性质&存储条件

参考文献

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GSK1820795A (GSK-1820795A)

生物&药学活性

物理化学性质&存储条件

参考文献

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