A2ti-1 | S100A10-ANXA2 inhibitor | Probechem Biochemicals

Chemical Structure : A2ti-1

CAS No.: 570390-00-0

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A2ti-1 (S100A10-ANXA2 heterotetramer (A2t) inhibitor)

货号: PC-27105Not For Human Use, Lab Use Only.

A2ti-1 (S100A10-ANXA2 heterotetramer inhibitor-1) is a specific small molecule Annexin A2 (ANXA2) inhibitor, inhibits Annexin A2-S100A10 protein interaction with IC50 of 24 uM (Annexin A2/S100A10 heterotetramer (A2t)).

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥4280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

A2ti-1 (S100A10-ANXA2 heterotetramer inhibitor-1) is a specific small molecule Annexin A2 (ANXA2) inhibitor, inhibits Annexin A2-S100A10 protein interaction with IC50 of 24 uM (Annexin A2/S100A10 heterotetramer (A2t)).
A2ti-1 remarkably inhibits Pseudorabies virus (PRV) propagation in vitro and protect mice from PRV infection in vivo.
A2ti-1 significantly reduces Porcine circovirus type 2 (PCV2) replication in host cells.
A2ti-1 reduced α-SMA protein levels and expression of profibrotic genes, indicating direct suppression of stellate cell activation in human hepatic stellate cells.
A2ti-1 significantly reduced fibrosis by lowering α-SMA levels, collagen deposition, and profibrotic gene expression, without altering steatosis in human multilineage liver organoids.
A2ti-1 inhibited hepatic stellate cell activation through a SMAD-independent mechanism involving reduced STAT3 phosphorylation.

物理化学性质&存储条件

分子量	382.48
分子式	C20H22N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Acetamide, 2-[[4-(2-ethylphenyl)-5-[(2-methylphenoxy)methyl]-4H-1,2,4-triazol-3-yl]thio]-

参考文献

1. Tummala R K Reddy, et al. ChemMedChem. 2012 Aug;7(8):1435-46.

2. Weng M, et al. J Virol. 2023 Mar 30;97(3):e0154522.

3. Türkal M, et al. EMBO Mol Med. 2026 Jun 10. doi: 10.1038/s44321-026-00464-y.

A2ti-1 (S100A10-ANXA2 heterotetramer (A2t) inhibitor)

生物&药学活性

物理化学性质&存储条件

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A2ti-1 (S100A10-ANXA2 heterotetramer (A2t) inhibitor)

生物&药学活性

物理化学性质&存储条件

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