| Cat. No. |
Product Name |
Information |
| PC-25769 |
BRD4310a
QcrB inhibitor
|
BRD4310a is a potent, small molecule inhibitor of QcrB inhibitor with MIC of 5.7 uM against wild-type Mtb strain H37Rv. |
| PC-25764 |
JT71
MrkH inhibitor
|
JT71 is a potent, specific small molecule inhibitor of MrkH activity, reduceds transcription of the type 3 fimbriae mrk operon, reduces K. pneumoniae mrkA promoter activity and biofilm formation. |
| PC-25652 |
JH-LPH-50
LpxH inhibitor
|
JH-LPH-50 is a highly potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor with Ki of 3.1 nM, and IC50 of 7.7 nM (K. pneumoniae LpxH), shows antibiotic activity with MIC of 3.3 ug/mL for wild-type K. pneumoniae (ATCC 10031). |
| PC-25641 |
D-IX216
Mtb RNAP inhibitor
|
D-IX216 is a potent, selective Mycobacterial RNA polymerase (Mtb RNAP) with IC50 of 100 nM, slows MtbRNAP translocation in a sequence-independent manner. |
| PC-25640 |
D-AAP1
Mtb RNAP inhibitor
|
D-AAP1 is a potent, selective, stereospecific activity against Mycobacterium tuberculosis RNA polymerase (Mtb RNAP) with IC50 of 0.4 uM, shows poor inhibition of other bacterial RNAP and human RNAP I, II, and III. |
| PC-25364 |
IMP-2380
NorA inhibitor
|
IMP-2380 is a potent, selective small molecule inhibitor of multidrug efflux pump NorA with EC50 of 7.1 nM in SOS response assay, and IC50 of 18 nM in the potentiation of ciprofloxacin-induced bacterial growth inhibition assay. |
| PC-25324 |
LPC-058
LpxC inhibitor
|
LPC-058 is a potent inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC), displays broad-spectrum antibiotic activity against antibiotic resistant Gram-negative pathogens. |
| PC-25241 |
Ganfeborole hydrochloride
Mtb LeuRS inhibitor
|
Ganfeborole hydrochloride (GSK3036656, GSK656) is a potent, highly selective, orally bioavailable Mtb Leucyl-tRNA synthetase (LeuRS) with IC50 of 0.2 uM. |
| PC-25151 |
UCM05
FtsZ inhibitor
|
UCM05 is a specfic small molecule inhibitor of bacterial cell division targeting the GTP-binding site of FtsZ with Kb of 43 uM, inhibits the growth of the Gram-positive bacterium B. subtilis with MIC of 100 uM, also is a fatty acid synthase (FASN) inhibitor wiht activity against HER2+ breast cancer. |
| PC-25077 |
Mtb LepB inhibitor 17af
LepB inhibitor
|
Mtb LepB inhibitor 17af is a potent, small molecule inhibitor of M. tuberculosis type I signal peptidase (LepB) with IC90 of 0.41 uM for LepB under-expressing (LepB-UE) strain of M. tuberculosis, shows IC50 of 1.2 uM against wild-type Mtb. |
| PC-24831 |
ANT3310 sodium
Serine β-Lactamase inhibitor
|
ANT3310 sodium (Pilabactam) is a potent, covalent broad-spectrum serine β-Lactamase inhibitor with IC50 of 1-175 nM against a panel of serine β-Lactamases. |
| PC-24737 |
Tarocin A
TarO inhibitor
|
Tarocin A is a specific inhibitor of UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase (TarO) with IC50 of 0.18 uM, inhibits the first step in wall teichoic acid biosynthesis, restore β-lactam efficacy against MRSA. |