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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-Tarocin A
Tarocin A

Chemical Structure : Tarocin A

CAS No.: 2095101-63-4

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Tarocin A

货号: PC-24737Not For Human Use, Lab Use Only.

Tarocin A is a specific inhibitor of UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase (TarO) with IC50 of 0.18 uM, inhibits the first step in wall teichoic acid biosynthesis, restore β-lactam efficacy against MRSA.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Tarocin A is a specific inhibitor of UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase (TarO) with IC50 of 0.18 uM, inhibits the first step in wall teichoic acid biosynthesis, restore β-lactam efficacy against MRSA.

物理化学性质&存储条件

分子量 481.39
分子式 C24H17F6NO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-3-(2-(naphthalen-1-yl)acetyl)oxazolidin-2-one

参考文献

1. Lee SH, et al. Sci Transl Med. 2016 Mar 9;8(329):329ra32.

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