JT71

Chemical Structure : JT71

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货号: PC-25764Not For Human Use, Lab Use Only.

JT71 is a potent, specific small molecule inhibitor of MrkH activity, reduceds transcription of the type 3 fimbriae mrk operon, reduces K. pneumoniae mrkA promoter activity and biofilm formation.

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250 mg		Get quote

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生物&药学活性

JT71 is a potent, specific small molecule inhibitor of MrkH activity, reduceds transcription of the type 3 fimbriae mrk operon, reduces K. pneumoniae mrkA promoter activity and biofilm formation.
JT71 (50 uM) inhibited MrkH-mediated mrkA promoter activity by approximately 50%.
JT71 inhibits transcription from both the mrkA and mrkH promoters, does not impair bacterial viability.
JT71 (50 uM) reduces type 3 fimbriae production of K. pneumoniae.
JT71 inhibits biofilm formation in other type 3 fimbriated K. pneumoniae and Citrobacter koseri isolates.
JT71 inhibits biofilm formation independently of c-di-GMP abundance.

物理化学性质&存储条件

分子量	326.41
分子式	C18H18N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-cyano-5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)-2-methoxybenzamide

参考文献

1. Wilksch JJ, et al. NPJ Biofilms Microbiomes. 2025 Nov 20;11(1):212.

JT71

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物理化学性质&存储条件

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JT71

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物理化学性质&存储条件

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