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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial

Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name Information
PC-21689

BDM91288

AcrB efflux pump inhibitor

BDM91288 is a pyridylpiperazine-based AcrB efflux pump inhibitor, potentiates the activity of a panel of antibiotics against K. pneumoniae.
PC-21661

TBAJ-5307

Non-tuberculous mycobacteria inhibitor

TBAJ-5307 is a broad spectrum anti-non-tuberculous mycobacteria (NTM) inhibitor targeting FO-domain of F1FO-ATP synthase, shows MIC50 of 4.5 nM and 6 nM against the Mab subsp. abscessus smooth strain and rough strain respectively.
PC-21552

SMT-738

LolCDE inhibitor

SMT-738 is a small-molecule inhibitor of bacterial lipoprotein transport complex (LolCDE), shows potent and highly selective antimicrobial activity.
PC-21546

SQ109

Mtb MmpL3 inhibitor

SQ109 (NSC 722041) is an ethambutol (EMB) analog and antitubercular agent targeting MmpL3, shows MICs of 1-0.5 uM.
PC-21349

EPM35

Bacterial efflux pump modulator

EPM35 (Efflux pump modulator 35) is a small molecule that bind AcrB (KD=0.29 uM), inhibit AcrAB-TolC and modulates bacterial efflux pump activity, reduces bacterial intracellular load.
PC-21141

KKL-55

Bacterial EF-Tu inhibitor

KKL-55 is a specific small molecule inhibitor of bacterial trans-translation by binding to longation factor thermo-unstable (EF-Tu, Kd=2 uM), inhibits binding between EF-Tu and tmRNA but not between EF-Tu and tRNA, has broad-spectrum antibiotic activity.
PC-21019

LPC-233

LpxC inhibitor

LPC-233 (LPC233) is a highly potent and specific inhibitor of UDP-3-O-(R-3-hydroxyacyl)-N-acetylglucosamine deacetylase LpxC (Ki=8.9 pM), specifically inhibits lipid A synthesis and displays outstanding antibiotic activities.
PC-20744

MAC13772

BioA inhibitor

MAC13772 is a small molecule inhibitor of bacterial enzyme BioA with IC50 of 250 nM, the antepenultimate step in biotin biosynthesis, MAC13772 inhibits biotin biosynthesis.
PC-20706

Durlobactam sodium

Beta-lactamase inhibitor

Durlobactam (ETX2514) sodium is a broad-spectrum β-lactamase inhibitor with IC50 of 4, 14 and 190 nM for class A β-lactamase KPC-2, class AmpC and class D OXA-24, respectively.
PC-20585

MAC13243

LolA inhibitor

MAC13243 is a small molecule inhibitor of the bacterial lipoprotein targeting chaperone LolA (Kd=7.5 uM), exhibits potent Gram-negative antibacterial activity with MIC value of 4 ug/mL (Pseudomonas aeruginosa PA01).
PC-20570

ML328

Bacterial AddAB complex inhibitor

ML328 is a first-in-class, dual inhibitor of bacterial AddAB and RecBCD helicase-nucleases with IC50 of 15.7 and 4.8 uM, respectively.
PC-20322

Regacin

RegA inhibitor

Regacin is a potent, specific inhibitor of bacterial AraC-like virulence regulator RegA with IC50 of 1.7 uM.

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