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Kalamycin

Chemical Structure : Kalamycin

CAS No.: 11048-15-0

Kalamycin (Kalafungin, U-19718, NSC137443)

货号: PC-27208Not For Human Use, Lab Use Only.

Kalamycin (Kalafungin, U-19718, NSC137443) is an antibiotic, antimicrobial agent and β-lactamase inhibitor from marine Streptomyces, also is a potent inhibitor of METTL1 methyltransferase activity with IC50 of 8.9 uM, demonstrates potent antileukemia efficacy, also shows inhibitory activities against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Kalamycin (Kalafungin, U-19718, NSC137443) is an antibiotic, antimicrobial agent and β-lactamase inhibitor from marine Streptomyces, also is a potent inhibitor of METTL1 methyltransferase activity with IC50 of 8.9 uM, demonstrates potent antileukemia efficacy, also shows inhibitory activities against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria.

物理化学性质&存储条件

分子量 302.24
分子式 C15H10O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(3aS,5S,11bS)-7-Hydroxy-5-methyl-3aH-benzo[g][1,3]dioxolo[4,5-c]isochromene-2,6,11(5H,11bH)-trione

参考文献

1. Johnson LE, et al. 1968 Dec;16(12):1815-21.

2. Ren L, et al. Blood. 2026 Jun 18;147(25):3069-3085.

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