Bacterial compound (inhibitors, antagonists)-ProbeChem.com

Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-45925	Moxifloxacin hydrochloride Antibiotic, DNA gyrase inhibitor	Moxifloxacin hydrochloride (BAY 12-8039) is a fourth-generation synthetic fluoroquinolone, broad-spectrum antibacterial agent that is active against both Gram-positive and Gram-negative bacteria, inhibits DNA gyrase and topoisomerase IV.
PC-42665	Gatifloxacin Bacterial DNA gyrase inhibitor	Gatifloxacin (PD 135432, AM1155) is a fourth-generation fluoroquinolone antibiotic that inhibits the bacterial DNA gyrase and topoisomerase IV.
PC-42048	Faropenem daloxate Beta-lactam antibiotic	Faropenem daloxate (Faropenem medoxil) is a daloxate ester prodrug of Faropenem with broad-spectrum antibacterial activity against many gram-positive and gram-negative aerobes and anaerobes, a beta-lactam antibiotic.
PC-42714	Pretomanid Mtb inhibitor	Pretomanid (PA-824) is an anti-tuberculosis agent that inhibits the synthesis of protein and cell wall lipid.
PC-28185	MtbIMPDH inhibitor 31 Mtb GuaB inhibitor	MtbIMPDH inhibitor 31 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB, MtbIMPDH) with IC50 of 0.52 uM.
PC-28184	MtbIMPDH2 inhibitor P41 GuaB2 inhibitor	MtbIMPDH2 inhibitor P41 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB, MtbIMPDH) with Ki app of 17 nM for MtbIMPDH2ΔCBS, displays significant activity against Mtb strain H37Rv in minimal BSA-free medium with MIC of 5 uM.
PC-28181	Mtb GuaB-IN-2 Mtb GuaB inhibitor	Mtb GuaB-IN-2 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB, IMPDH) with IC50 of 0.2 nM.
PC-28180	Mtb GuaB-IN-1 Mtb GuaB inhibitor	Mtb GuaB-IN-1 (Compound 15) is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB2, IMPDH) with IC50 of 1.7 nM, and MIC of0.26 uM for M.tb H37Ra.
PC-28120	Sulfamethoxazole Antibiotic, DHPS inhibitor	Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic for various bacterial, interferes with folic acid synthesis in susceptible bacteria, is a competitive dihydropteroate synthase (DHPS) inhibitor.
PC-27825	TrmD-IN-4 TrmD inhibitor	TrmD-IN-4 is a potent, covalent inhibitor of bacterial tRNA (m1G37) methyltransferase (TrmD) with IC50 of 4.43 uM, with minimal inhibition of human Trm5, shows selective growth inhibition in bacteria expressing TrmD.
PC-27824	TrmD-IN-3 TrmD inhibitor	TrmD-IN-3 is a potent, covalent inhibitor of bacterial tRNA (m1G37) methyltransferase (TrmD) with IC50 of 1.17 uM for E. coli TrmD, with minimal inhibition of human Trm5 (IC50=2.17 mM), shows selective growth inhibition in bacteria expressing TrmD.
PC-27823	TrmD-IN-2 TrmD inhibitor	TrmD-IN-2 is a potent, covalent inhibitor of bacterial tRNA (m1G37) methyltransferase (TrmD) with IC50 of 0.85 uM for E. coli TrmD, with minimal inhibition of human Trm5 (IC50=1.88 mM), shows selective growth inhibition in bacteria expressing TrmD.

PREV 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 272829 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 NEXT