Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-45269	Cefditoren pivoxil Antibiotic	Cefditoren pivoxil is a third-generation cephalosporin antibiotic that has been used to treat bacterial infections of the skin and respiratory tract, including bronchitis, pneumonia, and tonsillitis.
PC-45234	Minocycline hydrochloride Antibiotic	Minocycline hydrochloride is a tetracycline antibiotic with neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects, inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, also is a hypoxia-inducible factor (HIF)-1α inhibitor.
PC-45750	Vaborbactam serine β-lactamase inhibitor	Vaborbactam (RPX-7009) is a serine β-lactamase inhibitor that notably restores the activity of carbapenems against KPC-producing strains.
PC-45148	Rifabutin Antibiotic	Rifabutin (Ansamycin, LM-427) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties, inhibits DNA-dependent RNA polymerase.
PC-45277	Garenoxacin mesylate hydrate Antibiotic	Garenoxacin mesylate hydrate (BMS284756) is a quinolone antibiotic for the treatment of Gram-positive and Gram-negative bacterial infections.
PC-45276	Garenoxacin Antibiotic	Garenoxacin (BMS284756) is a quinolone antibiotic for the treatment of Gram-positive and Gram-negative bacterial infections.
PC-42192	DprE1-IN-25 DprE1 inhibitor	DprE1-IN-25 is a potent, noncovalent DprE1 inhibitor with IC50 of 43 nM, shows activity against Mycobacterium tuberculosis (Mtb) in vitro with MIC of 0.39 uM.
PC-45087	AFN-1252 FabI inhibitor	AFN-1252 (API-1252, Debio 1452) is a potent inhibitor of bacterial enoyl-ACP reductase FabI.
PC-42189	Nanchangmycin Antibiotic	Nanchangmycin (Nanchangmycin A) is a polyether ionophore antibiotic isolated from Streptomyces nanchangensis NS3226 that shows antibacterial and antiviral properties.
PC-45426	MUT056399 Fabl inhibitor	MUT056399 (FAB-001) is a novel, highly potent inhibitor of the FabI enzyme of both Staphylococcus aureus and Escherichia coli.
PC-45070	Relebactam β-lactamase inhibitor	Relebactam (MK-7655) is a novel β-lactamase inhibitor that inhibited both class A and C β-lactamases in vitro.
PC-45372	Dalbavancin Antibiotic	Dalbavancin (MDL-63397, BI-397) is a novel second-generation lipoglycopeptide antibiotic with MIC90 values of 0.06 μg/mL and 0.25 μg/mL for Staphylococcus aureus and Bacillus anthracis, respectively.

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