| Cat. No. |
Product Name |
Information |
| PC-27472 |
Luxafimloc
FimH inhibitor
|
Luxafimloc (GSK3882347) is a small molecule Escherichia coli fimbrial (FimH) adhesin inhibitor. |
| PC-27208 |
Kalamycin
METTL1 inhibitor, Antibiotic
|
Kalamycin (Kalafungin, U-19718, NSC137443) is an antibiotic, antimicrobial agent and β-lactamase inhibitor from marine Streptomyces, also is a potent inhibitor of METTL1 methyltransferase activity with IC50 of 8.9 uM, demonstrates potent antileukemia efficacy, also shows inhibitory activities against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria. |
| PC-27159 |
UCP1172
DHFR inhibitor, Antifolate
|
UCP1172 is an antibacterial dihydrofolate reductase (DHFR) inhibitor with IC50 of 8.9 nM, 220 nM, 410 nM and 30 nM for S. aureus DfrB (wt SaDHFR), DfrG, DfrA and DfrK, inhibits MRSA isolates with MIC50 of 0.625 ug/mL for UCH MRSA 1 (dfrG). |
| PC-26790 |
Forazemin
Peptide deformylase inhibitor
|
Forazemin (BB-83698) is a potent, orally active peptide deformylase (PDF) inhibitor, shows antibacterial potency for gram-positive pathogens with MIC50 of 0.25 ug/mL and 0.06 ug/mL for Streptococcus pneumoniae and Moraxella catarrhalis. |
| PC-26666 |
MSU-155
MmpL3 inhibitor
|
MSU-155 is small molecule inhibitor targeting MmpL3 in Mycobacterium abscessus, has MIC50 of 0.21 uM and trigger a dose-dependent ATP increase with in Mycobacterium abscessus. |
| PC-26607 |
VNRX-14079
N. gonorrhoeae PBP2 inhibitor
|
VNRX-14079 is a specific Neisseria gonorrhoeae penicillin-binding protein (PBP2) inhibitor with IC50 of 1.7 uM for N. gonorrhoeae FA19 strain, exhibits potent antibacterial activity against multidrug-resistant N. gonorrhoeae through high-affinity binding to the PBP2. |
| PC-26321 |
Cefidelbaz
Cephalosporin antibiotic
|
Cefidelbaz is a cephalosporin antibiotic with significant antibacterial activity against gram-negative bacterium with MICs of 0.125-0.5, 0.125-0.5 and 0.125-2 μg/mL for carbapenem-resistant Acinetobacter baumannii (CRAB), Klebsiella pneumoniae (CRE) and Pseudomonas aeruginosa (CRPA), respectively. |
| PC-26097 |
CAI0019
E. faecium carbonic anhydrase inhibitor
|
CAI0019 (CAI-0019) is a potent, selective bacterial carbonic anhydrase (CA) inhibitor with Ki of 66.9 nM and 346 nM for E. faecium α-CA and E. faecium γ-CA. |
| PC-25836 |
BioA inhibitor C48
BioA inhibitor
|
BioA inhibitor C48 is a potent and selective inhibitor of bacterial aminotransferase BioA, a key enzyme in bacterial biotin biosynthesis, with Ki of 200 pM, displays sub-micromolar MICs against Mycobacterium tuberculosis (Mtb, H37Rv MIC50=93 nM) and nontuberculous mycobacteria. |
| PC-25769 |
BRD4310a
QcrB inhibitor
|
BRD4310a is a potent, small molecule inhibitor of QcrB inhibitor with MIC of 5.7 uM against wild-type Mtb strain H37Rv. |
| PC-25764 |
JT71
MrkH inhibitor
|
JT71 is a potent, specific small molecule inhibitor of MrkH activity, reduceds transcription of the type 3 fimbriae mrk operon, reduces K. pneumoniae mrkA promoter activity and biofilm formation. |
| PC-25652 |
JH-LPH-50
LpxH inhibitor
|
JH-LPH-50 is a highly potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor with Ki of 3.1 nM, and IC50 of 7.7 nM (K. pneumoniae LpxH), shows antibiotic activity with MIC of 3.3 ug/mL for wild-type K. pneumoniae (ATCC 10031). |
