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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-JH-LPH-50
JH-LPH-50

Chemical Structure : JH-LPH-50

CAS No.: 3053068-44-0

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JH-LPH-50

货号: PC-25652Not For Human Use, Lab Use Only.

JH-LPH-50 is a highly potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor with Ki of 3.1 nM, and IC50 of 7.7 nM (K. pneumoniae LpxH), shows antibiotic activity with MIC of 3.3 ug/mL for wild-type K. pneumoniae (ATCC 10031).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

JH-LPH-50 is a highly potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor with Ki of 3.1 nM, and IC50 of 7.7 nM (K. pneumoniae LpxH), shows antibiotic activity with MIC of 3.3 ug/mL for wild-type K. pneumoniae (ATCC 10031).

物理化学性质&存储条件

分子量 592.03
分子式 C24H29ClF3N5O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-(3-(4-((4-(3-chloro-5-(trifluoromethyl)phenyl)piperazin-1-yl)sulfonyl)phenyl)ureido)-N-hydroxyhexanamide

参考文献

1. Seung-Hwa Kwak, et al. ChemMedChem. 2023 Jun 1;18(11):e202300023.

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