Bacterial compound (inhibitors, antagonists)-ProbeChem.com

Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-24403	HilD inhibitor C26 S. Typhimurium HilD inhibitor	HilD inhibitor C26 is a specific small molecule inhibitor of S. Typhimurium transcriptional regulator HilD with IC50 of 16.9 uM and binds to HilD with an apparent Kd of 30.2 uM, inhibits the secretion of SipA with IC50 of 29.2 uM.
PC-24388	MBX-4132 Trans-translation inhibitor	MBX-4132 is a trans-translation inhibitor with IC50 of 0.6 uM and 0.4 uM in E. coli luciferase reporter assay and in vitro reconstituted assays respectively, exhibits potent broad-spectrum antibiotic activity against Gram-positive species and many Gram-negative species.
PC-24304	Rifampin Antibiotic	Rifampin (Rifampicin) is a potent and broad spectrum antibiotic against bacterial pathogens, also has anti-influenza virus and anti-orthopoxvirus activities.
PC-24236	FBX-1991 H. pylori FabX inhibitor	FBX-1991 is a potent, specific small molecule inhibitor of Helicobacter pylori (H. pylori) dehydrogenase/isomerase FabX with IC50 of 0.158 uM, shows potent antibacterial activity against strain BHKS211 with MIC of 16 ug/mL.
PC-24195	Xeruborbactam disodium Beta-lactamase inhibitor	Xeruborbactam (QPX7728) disodium is an ultrabroad-spectrum beta-lactamase inhibitor, inhibits class A extended-spectrum beta-lactamases with IC50 of 1-3 nM, carbapenemases such as KPC (IC50, 2.9 nM), class C P99 (IC50, 22 nM).
PC-24024	MraY inhibitor 12a MraY inhibitor	MraY inhibitor 12a is a first-in-class, non-nucleoside inhibitor of bacterial enzyme MraY with IC50 of 25 uM, exhibits broad-spectrum antibacterial activity.
PC-23990	Enoxacin DNA Gyrase inhibitor	Enoxacin (Enoxacin sesquihydrate) is a fluoroquinolone antibiotic, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 µg/ml) and topoisomerase IV (IC50=26.5 µg/ml).
PC-23867	BRD1401 OprH-LPS inhibitor	BRD1401 is a P. aeruginosa-specific inhibitor targeting outer membrane protein OprH-LPS interaction, increases membrane fluidity.
PC-23757	STK848198 FtsH inhibitor	STK848198 is a small molecule antimicrobial compound with MIC of 2 ug/mL against S. aureus by targeting ATP-binding protein FtsH, inhibits methicillin-sensitive S. aureus, MSRA, VAN intermediate S. aureus (VISA), and DAP-resistant strains with MIC ranged from 0.5 to 8 ug/mL.
PC-23749	Benurestat Urease inhibitor	Benurestat is a reversible competitive inhibitor of gut bacterial urease, inhibits ammonia production by urease-encoding gut bacteria, inhibits urease activity in mouse fecal suspensions ex vivo with IC50 of 2.5 uM.
PC-23591	Miltefosine CCR5 agonist	Miltefosine is a phosphatidylcholine analog with anti-leishmanial activity, inhibits PI3K/Akt activity, shows broad spectrum antimicrobial, anti-leishmanial and anticoronaviral activity.
PC-23455	SQ31f Mycobacterial ATP synthase inhibitor	SQ31f is a potent non-tuberculous mycobacteria antibiotic by specifically targeting the mycobacterial F-ATP synthase, inhibits ATP hydrolysis with IC50 of 0.6 uM.

PREV 1 2 3 456 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 NEXT