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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-MBX-4132
MBX-4132

Chemical Structure : MBX-4132

CAS No.: 2286411-30-9

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MBX-4132 (MBX4132)

货号: PC-24388Not For Human Use, Lab Use Only.

MBX-4132 is a trans-translation inhibitor with IC50 of 0.6 uM and 0.4 uM in E. coli luciferase reporter assay and in vitro reconstituted assays respectively, exhibits potent broad-spectrum antibiotic activity against Gram-positive species and many Gram-negative species.

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5 mg ￥580 In stock
10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MBX-4132 is a trans-translation inhibitor with IC50 of 0.6 uM and 0.4 uM in E. coli luciferase reporter assay and in vitro reconstituted assays respectively, exhibits potent broad-spectrum antibiotic activity against Gram-positive species and many Gram-negative species.
MBX-4132 is highly effective against all tested clinical isolates of N. gonorrhoeae, including MDR strains (N. gonorrhoeae, MIC90=0.34 ug/mL).
MBX-4132 is bactericidal against N. gonorrhoeae at concentrations ≥ 4X MIC.
MBX-4132 (10 mg/kg) clears infection by a multiple-antibiotic resistant N. gonorrhoeae strain in a murine infection model.
MBX-4132 binds to a unique site near the peptidyl-transfer center and significantly alter the conformation of ribosomal protein bL27.

物理化学性质&存储条件

分子量 338.34
分子式 C18H15FN4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2(1H)-Isoquinolinecarboxamide,N-[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]-3,4-dihydro-

参考文献

1. Varshney A, et al. ACS Infect Dis. 2025 Apr 9. doi: 10.1021/acsinfecdis.4c00963.

2. Aron ZD, et al. Nat Commun. 2021 Mar 19;12(1):1799.

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